We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log 10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV—CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences—is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence.

This article presents the application of the ring-on-ring test to investigate some of the important factors affecting the abrasive and corrosion wear of a face seal used in the sugar industry. The test involves the sliding contact between two steel rings working in different conditions such as mechanic, abrasive, corrosive extortions and its combination. Rings were made of the C45 steel and the surface layers were modified by heat and thermochemical treatment such as normalizing, flame hardening, nitriding and chrome diffusion. Maximum wear of the sample after tests under mechanic, abrasive and corrosion extortion were obtained. For C45 steel without surface modification the biggest wear was obtained for mechanical, abrasive and corrosive extortion and equals 0.0138 g. This value was three times bigger than the result for the mechanical extortion and ten times than for the corrosive conditions. For individual research options the percentage increase or decrease in wear resistance in relation to the normalized surface layer was determined. In the corrosive extortion the highest increase (90%) of wear resistance was recorded for the chrome layer relative to normalizing sample. The main conclusion of the paper is that the wear effect caused by all factors—mechanical, abrasive and corrosive—is not a straight sum of values of wear.

Background: Tenofovir disoproxil fumarate is a prodrug of tenofovir diphosphate that exposes patients to renal toxicity over the long term. Tenofovir alafenamide, a new prodrug, now makes it possible to reduce toxicity, but at the cost of an alteration in lipid profile. There is currently no recommendation for follow-up of lipid profile when switching from tenofovir disoproxil fumarate to tenofovir alafenamide. Objective: Our study aimed to evaluate the effects on renal function and lipid profile of a switch from tenofovir disoproxil fumarate to tenofovir alafenamide, and the consequences for patient management. Methods: Demographic, clinical and biological data was recorded from a retrospective clinical cohort study in real-life, including patients who switched from tenofovir disoproxil fumarate to tenofovir alafenamide. A descriptive analysis of the study population, with comparison of biological parameters using the paired Student t test for paired data was performed. Results: From January 2016 to January 2019, a total of 103 patients were included. There was no significant difference in renal function before vs after the switch in therapy (p=0.29 for creatinine, p=0.30 for phosphoremia). We observed a change in lipid profile, with a significant increase in total cholesterol (p=0.0006), HDL cholesterol (p=0.0055) and triglycerides (p=0.0242). Four patients received lipid-lowering therapy after switching. Conclusion: In patients who switch from tenofovir disoproxil fumarate to tenofovir alafenamide, lipid profile is altered, and may require initiation of lipid-lowering therapy. It seems necessary to monitor lipid parameters after this switch, despite the absence of an official recommendation.

This article presents the results of tests conducted on the average and instantaneous friction coefficients of railway vehicle disc brakes. The tests were carried out independently of various states of wear on the friction linings and the brake disc. The requirements of the International Union of Railways (UIC) regarding the approval of brake linings for use were taken into account. Based on many years of research using a brake bench to test railway disc brakes, the authors developed multiple regression models for the average friction coefficient and fluctuations (tolerances) in the instantaneous friction coefficient and achieved 870 results. The models proposed three types of variables: the input braking parameters (speed, pressure, and mass to be braked), operational parameters (the wear on the friction linings and the brake disc), and design parameters (perforations in the form of holes on the disc surface). The above two models were validated on the basis of 384 brakes, and in subsequent stages a further evaluation was performed. The coefficients were determined to be, respectively, 0.99 for the model of the average friction coefficient and 0.71 for the model of tolerance (fluctuations) of the instantaneous friction coefficient.

Elements of belt conveyors, like other machine parts, are subject to wear processes. The conveyors transporting the spoil in the quartz sand mine are exposed to accelerated wear due to the effect of quartz on metal elements. Intensive wear of metal parts leads to downtime and the need to replace damage parts which generates additional costs. Therefore, it is important to perform surface treatment of metal elements, which will allow to extend the operation time of belt conveyors by reducing wear. The main objective of the article is to determine the impact of the pad welding process of the surface layer of metal elements on the abrasive wear of elements working in the metal–quartz sand–rubber conditions used in belt conveyors. In this research study, three different types of electrodes were used for pad welding the surface. The wear results obtained on the test stand were compared to wear of the basic element without surface treatment. The average wear value of the samples padded with electrode 3 was about 25% lower than the samples without surface treatment. The main mechanism of sample wear was the abrasion process due to the interaction between the steel surface and hard sand particles. The results presented in the article are important not only for belt conveyor elements but also for other machine parts where it is desirable to reduce abrasive wear.