The Photodetector Array Camera and Spectrometer (PACS) is one of the three science instruments on ESA's far infrared and submillimetre observatory. It employs two Ge:Ga photoconductor arrays (stressed and unstressed) with 16 × 25 pixels, each, and two filled silicon bolometer arrays with 16 × 32 and 32 × 64 pixels, respectively, to perform integral-field spectroscopy and imaging photometry in the 60−210 μm wavelength regime. In photometry mode, it simultaneously images two bands, 60−85 μm or 85−125 μm and 125−210 μm, over a field of view of ∼1.75 × 3.5 , with close to Nyquist beam sampling in each band. In spectroscopy mode, it images a field of 47 × 47 , resolved into 5 × 5 pixels, with an instantaneous spectral coverage of ∼ 1500 km s −1 and a spectral resolution of ∼175 km s −1 . We summarise the design of the instrument, describe observing modes, calibration, and data analysis methods, and present our current assessment of the in-orbit performance of the instrument based on the performance verification tests. PACS is fully operational, and the achieved performance is close to or better than the pre-launch predictions. Key words. space vehicles: instruments -instrumentation: photometers -instrumentation: spectrographsHerschel is an ESA space observatory with science instruments provided by European-led Principal Investigator consortia and with important participation from NASA.

This paper characterizes the actual science performance of the James Webb Space Telescope (JWST), as determined from the six month commissioning period. We summarize the performance of the spacecraft, telescope, science instruments, and ground system, with an emphasis on differences from pre-launch expectations. Commissioning has made clear that JWST is fully capable of achieving the discoveries for which it was built. Moreover, almost across the board, the science performance of JWST is better than expected; in most cases, JWST will go deeper faster than expected. The telescope and instrument suite have demonstrated the sensitivity, stability, image quality, and spectral range that are necessary to transform our understanding of the cosmos through observations spanning from near-earth asteroids to the most distant galaxies.

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Fluorescent cellular biomarkers play a prominent role in biosciences. Most of the available biomarkers have some drawbacks due to either physical and optical or cytotoxic properties. In view of this, we investigated the potential of green fluorescent nanodiamonds as biomarkers in living cells. Nanodiamonds were functionalized by attaching antibodies that target intracellular structures such as actin filaments and mitochondria. Then, the nanodiamond conjugates were transfected into HeLa cells. Transfections were mediated by 4(th)-generation dendrimers, cationic liposomes and protamine sulfate. Using fluorescence microscopy, we confirmed successful transfections of the nanodiamonds into HeLa cells. Nanodiamond fluorescence could be easily differentiated from cellular autofluorescence. Furthermore, nanodiamonds could be targeted selectively to intracellular structures. Therefore, nanodiamonds are a promising tool for intracellular assays.

Aims. FIR imaging of interacting galaxies allows locating even hidden sites of star formation and measuring of the relative strength of nuclear and extra-nuclear star formation. We want to resolve the star-forming sites in the nearby system of the Antennae. Methods. Thanks to the unprecedented sharpness and depth of the PACS camera onboard ESA's Herschel Space Observatory, it is possible for the first time to achieve a complete assessment of individual star-forming knots in the FIR with scan maps at 70, 100, and 160 μm. We used clump extraction photometry and SED diagnostics to derive the properties related to star-forming activity. Results. The PACS 70, 100, and 160 μm maps trace the knotty structure of the most recent star formation along an arc between the two nuclei in the overlap area. The resolution of the starburst knots and additional multi-wavelength data allow their individual star formation history and state to be analysed. In particular, the brightest knot in the mid-infrared (K1), east of the southern nucleus, exhibits the highest activity by far in terms of dust heating and star formation rate, efficiency, and density. With only 2 kpc in diameter, this area has a 10-1000 μm luminosity, which is as high as that of our Milky Way. It shows the highest deficiency in radio emission in the radio-to-FIR luminosity ratio and a lack of X-ray emission, classifying it as a very young complex. The brightest 100 and 160 μm emission region (K2), which is close to the collision front and consists of 3 knots, also shows a high star formation density and efficiency and lack of X-ray emission in its most obscured part, but an excess in the radio-to-FIR luminosity ratio. This suggests a young stage, too, but different conditions in its interstellar medium. Our results provide important checkpoints for numerical simulations of interacting galaxies when modelling the star formation and stellar feedback.