of histomorphologic diagnoses with special reference to the kappa statistic. APMIS 97: [689][690][691][692][693][694][695][696][697][698] 1989.Systems for classification and grading used in pathology should ideally be biologically meaningful and at least be reproducible from one pathologist to another. A statistical method to evaluate reproducibility (non-chance agreement) for several observers using nominal or ordinal categories has been developed and refined over the past few decadesthe kappa statistic. A high level of observed agreement among different pathologists can either signify a high level of reproducibility, if agreement by chance is low, or express a low level of reproducibility, if agreement by chance is almost as high as the observed agreement. Therefore, the observed agreement says nothing in itself, unless it is low. The kappa value, however, indicates how much better the observers are compared to a throw of the dice, and therefore gives the real credit to the agreement which was found. We have developed a user-friendly computer program for calculating inter-and intra-observer agreement of 2 or more observers. By calculating associations between different categories and different observers, the statistic furthermore obtains a function close to the parameter of accuracy. We recommend the use of the above method before a set of nominal or rank scale parameters are used for deciding prognosis and treatment of patients. By submitting a diskette the computer program will be available at no cost.

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Absiruct: 'The tolerance of paroxetinc (FG 7051). as well as its pharmacokinetics and reduction of 5-HT in blood, has been investigated in man. Three normal, healthy volunteers were administered the single doses 10, 25.50, and 75 mg orally, and three volunteers received 10. 25, and 50 mg per day for seven orfourteen days. No toxic effect on blood. kidney, liver. heart or general condition was found by chemical and physical examinations. The pharmacokinetic studies revealed a dose dependent systemic availability, a rather slow elimination (tl,2=approximately 16 hrs), a good fit to a one compartment open model,and analmost complete metabolism of the substance. 25 mg paroxetine per day gave a maximal reduction of 5-HT in the blood within 2-3 weeks (to approximately 0.03 pg/nil). The 5-HT levels returned to the basic levels during a three to four weeks drug-free period.

Simultaneous records of the pulse waves were obtained from the right common carotid artery and the right femoral artery by means of piezo-electric microphones in 26 per= sons whore ages ranged from 15 to 92 years. The time difference between the foot points of the waves from them two sites was termed Tar.A significant correlation was found between ToS and age, be= tween TOP and the systolic blood pressure and between Top and As described by Miller and White (1) and Geddes and Hoff (2), the pulse wave can be recorded by means of piezo-electric microphones placed externally above the artery. If T is the time difference between the foot points of two pulse waves recorded a t varying distances from the heart and D the length of the segment, the pulse wave velocity = D/T.

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