B27 negative uveitis under treatment with salazopyrin was admitted to the hospital due to the presence of high fever and mucocutaneous lesions. He had been vaccinated with the third dose against SARS-CoV-2 4 days before (mRNA-1273 -Moderna ® -while the first two doses had been mRNA-BNT162b2 -Pfizer-BioNTech ® -). On physical examination, he presented labial and palate mucositis, associating pain, swelling and meliceric crusts as well as erythematous-purpuric macular asymptomatic lesions located mainly on the periungual region of the fingers, palms, soles, and ears. Figure 1A-C. Slightly vesiculous (Some of them targetoid) millimetric erythematous lesions were also evident on the dorsal area. Figure 1D. Dermoscopy of the lesions revealed an erythematous-purpuric homogeneous pattern, without other relevant findings. Moreover, the patient presented both bilateral conjunctivitis and parotitis. Blood tests performed revealed a Reactive-C-Protein (RCP) of 119.1 mg/L as well as hyperferritinemia (553 ng/ml); cryoglobulins, and autoimmunity studies were anodyne. Chest X-ray examination was normal. A biopsy of one of the dorsal lesions was performed, revealing epidermal hyperplasia along with hyperkeratosis. Focal necrosis of the
An 11-year-old Caucasian boy with good general health and normal development presented for evaluation of a congenital nevus on his leg. The physician noted that he had an unusual appearance, including bitemporal scars resembling forceps marks. The mother told us that he had had linear scar-like depressions on both temples since birth. Furthermore, the pregnancy and birth had been normal, and the delivery had not required the use of forceps or other instruments. The parents were healthy and the patient was normal, except for mild strabismus and hypermetropia. Examination revealed bilateral, hyperpigmented, depressed, sharply demarcated atrophic areas on the temples (Fig. 1). The other clinical manifestations were low frontal hairline, dense eyebrows, thick lips, long upper and lower eyelashes and a bulbous nose (Fig. 2).No other cranial or extracranial disorders were observed. Examination of his maternal grandmother revealed that she had similar scar-like lesions on both temples (Fig. 3). Histologic examination of a 3 mm punch biopsy specimen from a lesion on his right temple showed a thinned epidermis and dermis without skin appendages. Little elastic tissue was found in the dermis. Results of routine laboratory studies were within normal limits.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.