In eight out of 22 patients with mammary carcinoma, extract of tumour tissue induced inhibition of autologous leukocyte migration in vitro, demonstrating a state of cellular (delayed type) hypersensitivity. Non‐tumorous tissue did not inhibit migration. The effect of the carcinoma extracts was not due to non‐specific toxicity, since the migration of leukocytes from matched controls was not affected by the extracts.
In nine cases of benign mammary lesions, extracts of autologous mammary tissue did not induce inhibition of migration.
Preliminary results of follow‐up studies in some of the carcinoma patients are reported.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.