We demonstrated that Web-based training is an effective tool for teaching dermoscopy.
Purpose To determine the ocular alterations occurring in alopecia areata with regard to the lens and fundus.Methods Seventy-five patients with alopecia areata were examined. Seventy healthy control patients unaffected by skin, ocular or systemic disorders were also studied.Results Symptomless punctate lens opacities were found in 38 (51%) patients, whereas only 2 (3%) control patients had similar lens changes. Fundus alterations were found in 31 (41 %) cases of alopecia areata and in only 16 (23%) controls. this study was to investigate the prevalence and appearance of the ocular changes occurring in AA. Conclusions Patients and methodsSeventy-five patients (25 men, 50 women; age range 7-61 years) with AA who were seen for dermatological reasons at the Dermatology Institute of the University of Rome 'La Sapienza' were referred for ophthalmological examination as part of the study and solely because of the presence of AA. All patients were subjected to the following tests: visual acuity, applanation tonometry, anterior segment biomicroscopy with study of the lens and fundus ophthalmoscopy after full pharmacological mydriasis. Seventy healthy control patients (25 men, 45 women; chosen to be comparable in age to the AA patients) unaffected by skin, ocular or systemic disorders were also studied. The cases of AA were divided into groups designated as: universalis (complete loss of scalp and body hair), totalis (complete loss of scalp hair) and areata (incomplete loss of the hair from the scalp, beard or other body areas). ResultsThe personal history of various diseases in the AA patients is shown in Table 1. In 24 (32%) there was thyroid pathology and in 17 (23%) there was a history of atopic dermatitis. Two patients suffered from vitiligo, 3 had anaemia (microcytaemia), 3 were affected with diabetes mellitus, 1 had Down's syndrome and 15 patients (20%) had neuropsychiatric problems. The patients in the control group were unaffected by skin, ocular or systemic disorders. Even though they were chosen to be of ages comparable to the patients with AA, statistical analysis with Student's t-test showed a lower (t = 2.3; d.f. = 144; p = 0.02) mean age in the AA group (30.4 years, SD = 13.1) compared with the control group (36.2 years, SD = 17.2), Table 2 shows the various modalities of treatment undergone by the AA patients in the past.Eye (1999) 13. 643-M6
Resveratrol, a natural product with a stilbene structure, exerts profound proapoptotic activity in human cancer cells, by triggering the accumulation of ceramide, a bioactive sphingolipid. We studied the biological effects of seven methoxylated and/or naphthalene-based resveratrol analogues and compared these compounds with resveratrol with the objective to identify an analogue with higher ceramide-mediated proapoptotic activity relative to resveratrol. Here we show that the compound with three hydroxyls and a naphthalene ring is the most effective in triggering apoptosis coupled to the induction of endogenous ceramide in human cancer cells.
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