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The notion of selective opening attacks (SOAs) was first introduced by Dwork et al. at FOCS'99. Informally, an encryption scheme is SOA secure if an adversary is given a vector of ciphertexts and can adaptively corrupt some fraction of them by obtaining not only their messages but also their randomness, the uncorrupted ciphertexts retain secure. Provably achieving security against SOA has been proven extremely challenging. In this paper, we propose a security model to capture simulation‐based selective opening chosen‐plaintext attacks (SIM‐SO‐CPA) for certificateless encryption. We provide a concrete construction and prove its security in our simulation‐based selective opening chosen‐plaintext attack security model, based on the real or random and computational Diffie–Hellman assumptions. Compared with previous SOA‐secure public key encryption and identity‐based encryption, our certificateless encryption scheme is more simple and efficient. Copyright © 2017 John Wiley & Sons, Ltd.

Background The C‐reactive protein (CRP)/albumin (Alb) ratio (CAR) is a basic inflammatory factor that has been related to poor survival of patients with various tumors. Our research retrospectively examined the relationship between the CAR and the prognosis of hepatocellular carcinoma (HCC). Methods This study included 172 patients with HCC who were treated with transcatheter arterial chemoembolization (TACE) and radiofrequency ablation (RFA). Results The CAR was weakly related to the neutrophil/lymphocyte ratio (NLR, r = .159, P = .037) and the lymphocyte/monocyte ratio (LMR, r = −.263, P = .001). The Glasgow Prognostic Score (GPS) (0/1‐2) was related to liver cirrhosis (P = .003), tumor number (P = .02), Child‐Pugh grade (P = .001), the platelet/lymphocyte ratio (PLR, P = .006), and the LMR (P = .021). Correlation analysis demonstrated that an elevated CAR was markedly correlated with the tumor size (P = .019), alpha‐fetoprotein (AFP) level (P = .033), thrombosis of the portal vein (P = .004), the NLR (P = .036), and the LMR (P = .001). Multivariate analysis indicated that the prognosis of the CAR‐High and NLR‐High cohort (mOS = 7 months) was significantly worse than those of the CAR‐High or NLR‐High cohort (mOS = 15 months) and the CAR‐Low and NLR‐Low cohort (mOS = 26.5 months). Conclusions Combination of the NLR and the CAR represents a convenient, quick, and noninvasive biological marker that could improve prognostic prediction in patients with HCC.

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