The z-test based on the Kappa statistic is commonly used to infer superiority of one map production method over another. Typically the same reference data set is used to calculate and next compare the Kappa's of the two maps. This data structure easily leads to dependence between the two error-matrices. This may result in overly large variance estimates and too conservative inference about the difference in accuracy between the two methods. Tests considering the dependency between the error matrices would be more sensitive in such case. In this article we compare the performance of two such tests, a randomization and McNemar's test, with the traditional z-test. We compared 16 alternative methods to classify salt marsh vegetation in The Netherlands. The error matrices were positively associated in all 120 possible comparisons of pairs of classification methods. This suggests that dependency between pairs of error matrices used in classifier comparison is a common phenomenon. Both the randomization and McNemar test gave lower p values and rejected the null hypothesis of equal performance more frequently than the z-test. We therefore recommend considering their use.

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To achieve accurate segmentation of thyroid nodule ultrasound images, obtain information on the physiological parameters of the lesion area and guide the clinical formulation of individualized treatment plan, an improved network based on the U2‐Net model is proposed in this paper. Thyroid images of 264 patients and 215 healthy volunteers at the First Hospital of Shanxi Medical University from February 2016 to June 2022 are studied, and the digital database thyroid image (DDTI) data set is proposed for data expansion. The experimental results show that the Dice coefficient on the test set was 80.58%, and the mean intersection over union was 81.21%. The improved U2‐Net model has the best segmentation accuracy compared with similar models, realizes the automatic segmentation of thyroid nodules, provides help for manual segmentation, and has good application prospects and clinical value.