The clinical efficacy and safety of Netilmicin (NTL) and Sisomicin (SISO) were compared in this randamized, double-blind study of 226 patients with respiratory tract infections .
Acid cholesteryl ester hydrolase activity of mononuclear leukocytes was measured in 52 Type 2 (non-insulindependent) diabetic patients. Enzyme activity was significantly lower in the diabetic patients than in 14 age-matched control subjects (0.89+0.08 (mean+s.E.) vs. 2.20 ±0.17 nmol/mg protein/hr, p <0.01). In diabetic patients undergoing diet treatment only, the enzyme activity was significantly lower in poorly controlled patients than in well controlled patients (0.43±0.03 vs. 1.15±0.24 nmol/mg protein/hr, p <0.01). In the diabetic patients, there was a significant negative correlation between the enzyme activity and serum total cholesterol or low density lipoprotein cholesterol level (r= -0.361, p <0.01, n =52 or r = -0.630, p <0.01, n = 28). These results suggest that a low level of acid Cholesteryl ester hydrolase activity in mononuclear leukocyte might play an important role in the progression of atherosclerosis in Type 2 diabetes. cholesteryl ester hydrolase ; mononuclear leukocyte ; Type 2 (non-insulin-dependent) diabetes ; atherosclerosis ; low density lipoprotein cholesterol It is well known that cholesteryl ester (CE) is accumulated in foam cells of atheromatous lesions, and accumulation is accelerated by a decreasing of acid CE hydrolase activity in lysosomes of the aortic wall (Small 1977). Also, this enzyme activity is considered to play an important role in the appearance and development of atherosclerosis in diabetes mellitus. It has been reported that this enzyme activity of the aortic wall in streptozotocin-induced diabetic rats was reduced and normalized by insulin treatment (Wolinsky et al. 1978). Further, it has been reported that the acid CE hydrolase activity in lysosoms of mononuclear leukocytes was markedly stimulated by insulin treatment in Type 2 (non-insulindependent) diabetic patients. However, it was not indicated whether the enzyme
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