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Background:The function of the C. elegans mitochondrial uncoupling protein 4 (ceUCP4) has not been characterized. Results: Worms deficient in ceUCP4 displayed hypometabolic phenotypes and complex II dysfunction that corresponded with a significant loss of mitochondrial succinate import. Conclusion: ceUCP4 plays a novel role in the regulation of complex II by controlling succinate transport into mitochondria. Significance: Understanding how extramitochondrial succinate and ceUCP4 regulate complex II-mediated metabolism is critical for understanding the mechanisms of cellular respiration.

Gsta4/GSTA4 is a novel susceptibility gene for NMSC that affects risk in both mice and humans.