SUMMARYDespite an extensive literature indicating that mood disorders are a frequent psychiatric complication of epilepsy, reports continue to indicate that depression often goes unrecognized or untreated (Schmitz, 2005). The underdiagnosis of affective comorbidity in epilepsy is likely to have many sources: an insufficient sensitivity among epileptol-

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CM is associated with structural changes in brain regions involved in pain processing but also in affective and cognitive aspects of pain. Some GM alterations are correlated with headache frequency assessed in EM and CM. The findings support the assumption that chronic pain alters brain plasticity. GMV increase may reflect a remodeling of the central nervous system due to repetitive headache attacks leading to chronic sensitization and a continuous ictal-like state of the brain in chronic migraineurs.

No microstructural white matter changes could be observed in middle-aged chronic and episodic migraineurs using DTI. CM does not seem to be a risk factor for progressive microstructural changes in DTI.