The theory that cancer may arise under conditions of reduced immune capacity is supported by observations of humans with immune deficiencies such as occur following organ transplants. However, no study on humans has been done in which the reference population was the same as that in which the cancer cases arose and in which there was a sufficiently long period of follow-up. Information on 5,692 Nordic recipients of renal transplants in 1964-1982 was linked with the national cancer registries (1964-1986) and population registries. Person-years at risk were calculated from the date of first transplantation until death or the end of the study period and were multiplied by the appropriate age- and calender-specific incidence rates to obtain the expected numbers of cancers. Standardized incidence ratios (SIR) were calculated after stratification by a number of recorded variables. Altogether, 32,392 person-years were accrued, and 471 cancers occurred, yielding overall SIR of 4.6 (95% CI, 4.0 to 5.2) for males and 4.5 (95% CI, 4.0 to 5.2) for females. Significant overall 2- to 5-fold excess risks in both sexes were seen for cancers of the colon, larynx, lung and bladder, and in men also for cancers of the prostate and testis. Notably high risks, 10-fold to 30-fold above expectation, were associated with cancers of the lip, skin (non-melanoma), kidney and endocrine glands, also with non-Hodgkin's lymphoma, and in women also with cancers of the cervix and vulva-vagina. Among a number of donor and recipient variables studied, including tissue types and compatibility (ABO, HLA, DR), age below 45 years at the time of transplantation was the most important determinant for increased risk at most sites. Kidney transplantation increases the risk of cancer in the short and in the long term, consistent with the theory that an impaired immune system allows carcinogenic factors to act. The tumor risk is small in comparison with the benefits of transplants, but patients should be followed up for signs of cancer.

Analysis of profiles of meteorological measurements from a 160 m high mast at the National Test Site for wind turbines at Høvsøre (Denmark) and at a 250 m high TV tower at Hamburg (Germany) shows that the wind profile based on surface-layer theory and Monin-Obukhov scaling is valid up to a height of 50-80 m. At higher levels deviations from the measurements progressively occur. For applied use an extension to the wind profile in the surface layer is formulated for the entire boundary layer, with emphasis on the lowest 200-300 m and considering only wind speeds above 3 m s −1 at 10 m height. The friction velocity is taken to decrease linearly through the boundary layer. The wind profile length scale is composed of three component length scales. In the surface layer the first length scale is taken to increase linearly with height with a stability correction following Monin-Obukhov similarity. Above the surface layer the second length scale (L MBL ) becomes independent of height but not of stability, and at the top of the boundary layer the third length scale is assumed to be negligible. A simple model for the combined length scale that controls the wind profile and its stability dependence is formulated by inverse summation. Based on these assumptions the wind profile for the entire boundary layer is derived. A parameterization of L MBL is formulated using the geostrophic drag law, which relates friction velocity and geostrophic wind. The empirical parameterization of the resistance law functions A and B in the geostrophic drag law is uncertain, making it impractical. Therefore an expression for the length scale, L MBL , for applied use is suggested, based on measurements from the two sites.

A prospective study of the prevalence and causes of persistent albuminuria (greater than 300 mg/24 hr) was conducted in non-insulin-dependent diabetic (NIDDM) patients, age less than 66 years, attending a diabetic clinic during 1987. All eligible patients (N = 370) were asked to collect at least one 24-hour urine sample for albumin analysis. Urine collection was obtained in 224 males and 139 females (98%). Fifty patients (7 women) suffered from persistent albuminuria (13.8%). The prevalence of albuminuria was significantly higher in males (19%) than in females (5%). A kidney biopsy was performed in 35 patients (70%). The kidney biopsies revealed diffuse and/or nodular diabetic glomerulosclerosis in 27 patients (77%), while the remaining eight patients (23%) had a variety of non-diabetic glomerulopathies, such as minimal lesion and mesangioproliferative glomerulonephritis. Diabetic retinopathy was present in 15 of 27 patients (56%) with diabetic glomerulosclerosis, while none of the eight patients with a non-diabetic glomerulopathy had retinopathy. Our cross sectional study has revealed a high prevalence of albuminuria and of non-diabetic glomerulopathy as a cause of this complication in NIDDM patients. Presence of diabetic retinopathy strongly suggests that a diabetic glomerulopathy is the cause of albuminuria. Albuminuric non-insulin-dependent diabetic patients without retinopathy require further evaluation, that is, kidney biopsy.

To identify the influence of wind shear and turbulence on wind turbine performance, flat terrain wind profiles are analysed up to a height of 160 m. The profiles' shapes are found to extend from no shear to high wind shear, and on many occasions, local maxima within the profiles are also observed. Assuming a certain turbine hub height, the profiles with hub-height wind speeds between 6 m s −1 and 8 m s −1 are normalized at 7 m s −1 and grouped to a number of mean shear profiles. The energy in the profiles varies considerably for the same hub-height wind speed. These profiles are then used as input to a Blade Element Momentum model that simulates the Siemens 3.6 MW wind turbine. The analysis is carried out as time series simulations where the electrical power is the primary characterization parameter. The results of the simulations indicate that wind speed measurements at different heights over the swept rotor area would allow the determination of the electrical power as a function of an 'equivalent wind speed' where wind shear and turbulence intensity are taken into account. Electrical power is found to correlate significantly better to the equivalent wind speed than to the single point hub-height wind speed. Figure 8. (a): Calculated power curves with fi xed and variable rotational speed. No shear; (b): Calculated power curves with fi xed and variable speed. Extreme shear specifi ed. 246 × 76 mm (500 × 500 DPI) 356 R. Wagner et al. ConclusionsLarge variations have been observed in the wind profi les over a fl at site. The results show that the profi les usually do not follow the logarithmic law; instead, their shape, in the case of fl at terrain, heavily depends upon the atmospheric conditions. These profi les were used as input to a sensitivity analysis concerning the power production as a function of a weighted ('equivalent') wind speed over the whole swept rotor area as compared with the results of the wind speed only at hub height. The results from the simulations indicate that measuring the wind speed at an increased number of points over the whole swept rotor area profi le, would improve the correlation between wind input and power output. These results support the necessity for the introduction of a new defi nition for power performance measurements using a distributed measurement of the wind over the swept rotor area instead of using only the hub-height wind speed.

We present an analysis of data from a measurement campaign performed at the Bolund peninsula in Denmark in the winter of [2007][2008]. Bolund is a small isolated hill exhibiting a significantly steep escarpment in the main wind direction. The physical shape of Bolund represents, in a scaled-down form, a typical wind turbine site in complex terrain. Because of its small size the effect of atmospheric stratification can be neglected, which makes the Bolund experiment ideal for the validation of neutral flow models and hence model scenarios most relevant to wind energy. We have carefully investigated the upstream conditions. With a 7-km fetch over water, the incoming flow is characterized as flow over flat terrain with a local roughness height based on the surface momentum flux. The nearly perfect upstream conditions are important in forming a meaningful quantitative description of the flow over the Bolund hill. Depending on the wind direction, we find a maximum speed-up of 30% at the hill top accompanied by a maximum 300% enhancement of turbulence intensity. A closer inspection reveals transient behaviour with recirculation zones. From the wind energy context, this implies that the best site for erecting a turbine based on resource constraints unfortunately also imposes a penalty of high dynamic loads. On the lee side of Bolund, recirculation occurs with the turbulence intensity remaining significantly enhanced even at one hill length downstream. Its transient behaviour and many recirculation zones place Bolund in a category in which the linear flow theory is not applicable.