Abstract:We have experimentally demonstrated a diodepumped passively mode-locked Nd:CLNGG-CNGG hybrid laser for the first time. By employing Nd:CLNGG and Nd:CNGG disordered crystals together as laser gain media, the mode-locked laser could generate much shorter pulses. With a semiconductor saturable absorber mirror (SESAM) as a mode locker, the laser emitted stable mode-locked pulses with a pulse width of 534 fs, a repetition rate of 88 MHz, and an average output power of 60 mW. To our best knowledge, this is the shortest pulse generated from SESAM mode-locked Nd-doped crystal lasers.Intensity, a.u.
Time, 50 ns/div 50 nsA typical mode-locked pulse train
Aims: To clarify the underlying synergistic antifungal mechanisms of retigeric acid B (RAB) in combination with azoles against Candida albicans.
Methods and Results: Increased accumulation of rhodamine 123 in C. albicans was measured by both spectrophotometric method and flow cytometry. The inhibitory properties to the drug efflux of C. albicans were determined spectrophotometrically. The decreased cellular ergosterol synthesis was measured using its unique spectrophotometric absorbance profile, and the downregulation expression levels of CDR1 and ERG11 were detected by real‐time reverse transcription polymerase chain reaction. Transmission electron microscopy investigation found the wrinkled cell membrane and the impaired cell wall.
Conclusions: RAB synergizes the antifungal effect of azoles against C. albicans by inhibiting efflux pump activity, targeting the ergosterol biosynthesis pathway and increasing the fluidity for the resulted ergosterol depletion.
Significance and Impact of the Study: Investigating the mechanism of the synergy between RAB and azoles against C. albicans will help us to uncover the antifungal roles of this lichen‐derived triterpene acid and find its possible clinical applications in overcoming fungal resistance.
Abstract:We report on a compact high-power passively modelocked Nd:LuVO4 laser by use of semiconductor saturable absorber mirror (SESAM). The laser generated clean CW modelocked pulses with an average output power of 8.6 W, a repetition rate of 144 MHz, and a pulse duration of 13.2 ps. By employing a three-mirror cavity scheme, the laser setup has only a footprint size of 70×30 cm 2 , which can be packaged to a portable laser system for convenient applications. Average output power vs. absorbed pump power
Abstract:We report an intracavity optical parametric oscillator at 1.57 µm based on non-critically nonlinear crystal KTP driven by an end-pumped acousto-optically Q-switched Nd:LuVO 4 crystal. The output characteristics of 1.57 µm were studied with different pulse repetition frequency. The pulse width of 5ns, the maximum peak power and pulse energy of 4.8 kW and 24 µJ were obtained, respectively, with pulse repetition frequency of 5 kHz. The compression ration of pulse width was six times for 1.06 µm to 1.57 µm.
The efficient second-Stokes generation at 1120 nm is obtained from a KTiOAsO4 (KTA) crystal. The relative Raman scattering cross sections of KTA with respect to YVO4 are determined by studying their spontaneous Raman scattering spectra at room temperature. A 30-mm-long KTA crystal is placed inside the cavity of a diode-end-pumped acousto-optically Q-switched Nd:YAG laser. With a pump power of 6.7 W and a pulse repetition rate of 20 kHz, the second-Stokes (1120 nm) power of 0.63 W is obtained, corresponding to a diode-to-second-Stokes conversion efficiency of 9.4%.
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