Objective To determine the optimum duration of oral anticoagulant therapy after an episode of deep vein thrombosis or pulmonary embolism, or both. Design Multicentre, prospective, randomised study with follow-up for one year. Setting 46 hospitals in United Kingdom. Participants Patients aged ≥18 with deep vein thrombosis or pulmonary embolism, or both.

A particular pattern of circadian variation of cardiovascular and cerebrovascular diseases has been reported in the literature. The circadian periodicity of ischaemic stroke with peak onset in the morning hours may not be a random event and could depend on some underlying precipitating and associated cardiovascular risk factors. In a prospective observational study, we observed that ischaemic stroke onset was significantly higher in late morning hours between 6.00 and 12.00 hours. Ischaemic heart disease and hypertension were significantly associated with the occurrence of late morning ischaemic strokes. Further studies in the future are needed to understand the significance of this association and whether these risk factors are implicated in the pathogenesis of stroke.

Post-traumatic growth can develop soon after stroke. Deliberate rumination is a key factor in post-traumatic growth. Both active coping and denial coping were associated with post-traumatic growth demonstrating the psychological complexity of poststroke adjustment. Implications for rehabilitation Therapists can expect stroke survivors to show post-traumatic growth in the first months after stroke. Therapists should look to promote post-traumatic growth and positive adjustment through working with survivors to increase active coping (attempts to deal effectively with the impact of stroke) and rumination (cognitive processing of the impact of the stroke). Since denial coping was also associated with posttraumatic growth, stroke survivors who maintain overly optimistic views about the severity and impact of their stroke are likely to benefit from therapists continually facilitating capacity for growth and well-being.

Unforeseen difficulties in the translation of our paradigm to a clinical setting required some deviations from the preregistered protocol. We explicitly detail these changes, discuss the accompanied additional challenges that can arise in clinical neurofeedback studies, and formulate recommendations for how these can be addressed. Taken together, this work provides new insights about the feasibility of motor imagery-based graded fMRI-NF training in MCA stroke survivors and serves as a first example for comprehensive study preregistration of an (fMRI) neurofeedback experiment.

[4, 5]. The trait is inherited in an autosomal dominant fashion and a mutation of the receptor site shared by meal and enema, and CT of the thorax, abdomen and pelvis, bronchoscopy and brushings also failed to reveal any abnormality.warfarin and vitamin K is postulated, although the locus of the mutation is unknown. He was commenced on full-dose ( porcine mucosal) heparin for 10 days and the warfarin dose was increased to 15 mg daily untilMeasurement of the plasma warfarin concentration may be helpful in all these circumstances, since at steady state, his INR had risen to 4.0, when his plasma warfarin concentration was measured at 3.1 mg l −1 . the reference range is 0.8 to 2.4 mg l −1 [6]. The reference range for warfarin clearance (calculated by dividing the daily Patients vary markedly in their requirement for warfarin, warfarin dose by the steady-state plasma concentration) is but 95% of subjects need more than 1 and less than 2.5 to 8.7 l day −1