This research investigated the effects of Ro15-4513 (Ro15), a partial inverse benzodiazepine agonist, on the drinking behavior of 23-1/2 hr fluid deprived rats. Water-deprived rats were maintained on a two-bottle regimen of a saccharin-ETOH solution along with tap water available for 30 min/day for several days. Following this acclimation period, animals were pretreated with either Ro15 (1.0, 2.5, and 5.0 mg/kg) or Tween-80 vehicle injections. Pretreatment with Ro15 at all doses tested resulted in a significant reduction of the saccharin-ETOH solution; however, Ro15 did not alter the rats' consumption of water. The effects of Ro15 on general fluid consumption was investigated in Experiment 2. Following acclimation to a two-bottle regimen of a saccharin-solution and tap water 30 min/day, naive animals were pretreated with Tween-80 vehicle or Ro15 injections. Ro15 failed to alter saccharin or water consumption. The results of this study support previous reports suggesting that Ro15 attenuates the oral consumption of ETOH; however, this effect does not appear to be due to a general suppression of fluid intake.
Previous studies have shown that increased stress, as measured by life-change scales, is associated with poor performance. The present study examined the effects of stress on the performance of 86 adult male runners in a half marathon. Subjects responded to a questionnaire from which several independent variables were derived. These variables were entered in a stepwise multiple regression to predict race times. The combination of age, weekly mileage, and number of races previously entered yielded a significant multiple R. However, stress was not significantly related to race times, and subsequent statistical analyses were carried out to explain this lack of significance. It was suggested that the effects of stress on athletic performance may be reduced by physical and psychological variables associated with exercise or that race performance is too well determined by physical variables to be affected by life changes.
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