The awareness, treatment, and control rates of hypertension for young adults are much lower than average. It is urgently needed to explore the variances of metabolic profiles for early diagnosis and treatment of hypertension. In current study, we applied a GC–MS based metabolomics platform coupled with a network approach to analyze plasma samples from young hypertensive men and age-matched healthy controls. Our findings confirmed distinct metabolic footprints of young hypertensive men. The significantly altered metabolites between two groups were enriched for the biological module of amino acids biosynthesis. The correlations of GC–MS metabolomics data were then visualized as networks based on Pearson correlation coefficient (threshold = 0.6). The plasma metabolites identified by GC–MS and the significantly altered metabolites (P < 0.05) between patients and controls were respectively included as nodes of a network. Statistical and topological characteristics of the networks were studied in detail. A few amino acids, glycine, lysine, and cystine, were screened as hub metabolites with higher values of degree (k), and also obtained highest scores of three centrality indices. The short average path lengths and high clustering coefficients of the networks revealed a small-world property, indicating that variances of these amino acids have a major impact on the metabolic change in young hypertensive men. These results suggested that disorders of amino acid metabolism might play an important role in predisposing young men to developing hypertension. The combination of metabolomics and network methods would provide another perspective on expounding the molecular mechanism underlying complex diseases.
Synthetic aperture radar (SAR) is an important means to detect ocean oil spills which cause serious damage to the marine ecosystem. However, the look-alikes, which have a similar behavior to oil slicks in SAR images, will reduce the oil spill detection accuracy. Therefore, a novel oil spill detection method based on multiple features of polarimetric SAR data is proposed to improve the detection accuracy in this paper. In this method, the self-similarity parameter, which is sensitive to the randomness of the scattering target, is introduced to enhance the discrimination ability between oil slicks and look-alikes. The proposed method uses the Random Forest classification combing self-similarity parameter with seven well-known features to improve oil spill detection accuracy. Evaluations and comparisons were conducted with Radarsat-2 and UAVSAR polarimetric SAR datasets, which shows that: (1) the oil spill detection accuracy of the proposed method reaches 92.99% and 82.25% in two datasets, respectively, which is higher than three well-known methods. (2) Compared with other seven polarimetric features, self-similarity parameter has the better oil spill detection capability in the scene with lower wind speed close to 2–3 m/s, while, when the wind speed is close to 9–12 m/s, it is more suitable for oil spill detection in the downwind scene where the microwave incident direction is similar to the sea surface wind direction and performs well in the scene with incidence angle range from 29.7° to 43.5°.
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