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We report the extension of an easy one-step synthesis of amino gembisphosphonates through the reaction of amides and lactams with trialkylphosphites.

The optimization of the one-step diphosphorylation reaction is reported. The synthesis of new α-aminobisphosphonates with four and six-membered rings and acyclic species with several substituents on the nitrogen and on the carbon atom bearing the two phosphorus atoms is described.