The title compound has been prepared and shown to be highly active against a wide variety of gram-positive and gram-negative bacteria in mice and chicks, as well as against a number of parasitic infections in rodents.
1.80 1.75 oc2h6 1.82 1.76 OCH(CH3)2 1.88 1.82 ch3 2.23 0.96 2.11 0.82 " 10% toluene solutions except for the 3-methyl compound which was 50% in chloroform. Chemical shifts given in (parts per million) from tetramethylsilane.A 30% solution shows the peaks shifted to 1.84 and 1.88 with incomplete resolution. The results were similar in benzene and for the other alkoxy substituents. In the case of the 3-methyl analog, the peaks were at 2.11 and 2.23 in CHC13 for the trans and cis isomers. When toluene is the solvent, care must be taken to avoid interference from the spinning side bands of the solvent methyl group.
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