Highlights d GAPDH is a clinical biomarker of DLBCL response to R-CHOP d GAPDH expression predicts B cell lymphoma metabolic status d GAPDH low B cell lymphomas are sensitive to mitochondrial metabolism inhibitors d DLBCL-GAPDH low R-CHOP refractory patients respond to specific metabolic inhibitors
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Key Points
Caloric restriction reduces Mcl-1 expression and sensitizes lymphoma cells to ABT-737 in vivo. Caloric restriction mimetics can sensitize lymphomas to ABT-737–induced death independently of p53 and of the main BH3-only proteins.
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