This study investigated whether and how pirenoxine (PRX) interacts with selenite or calcium ions, as these two ions have been proven respectively a factor leading to the formation of lens cataract. UV, NMR, and isothermal titration calorimetry (ITC) analysis indicated that PRX could bind maximum up to six selenite anions and the binding site preference was concentration dependent with the peripheral binding first followed by the π-π interactions with the aromatic moiety; while for calcium cation interaction the 3-carboxylate and β-ketoimine functional groups were responsible for chelating calcium ions. The results obtained by MP2/6-31+G(d) molecular orbital calculations provided theoretical evidence in support of the π-π interactions between selenite and the PRX aromatic framework, and further analysis of the binding energies with the aromatic moiety indicates that these interactions take place most likely at the benzoquinone (ring I) π-system. The calcium binding preferences with PRX were also determined based on the stabilization energy obtained by B3LYP/6-31+G(d) calculations, showing the binding preferences were site 2 > site 1 > site 3 > ring II, consistent with the experimental data. The in vitro study of the reduction of selenite or calcium ions-induced lens turbidity by PRX with ditopic recognition properties was thus demonstrated. These results may provide a rationale for using PRX as an anti-cataract agent and warrant further biological studies.
The clinical presentation of PIV infection in hospitalized children ranges from upper respiratory tract infection to croup, bronchiolitis and viral bronchopneumonia, with the different types of PIV infections giving rise to similar symptoms. The seasonal distribution of the different serotypes is, nevertheless, quite distinct.
ABsmm.-From the rootbark of Tuwaea d a t u , two new limonoids, 1 and 2, of the prieurianin class have been isolated and their structures established by spectroscopic means. Turraea mombasana C . DC. taken for the treatment of malaria and (Meliaceae) is a shrub found in East Afother fevers (1). Our investigation of the rica. In traditional medicine, the roots are MeOH extract of the root bark has reused for the treatment of excess bile and sulted in the isolation of two new as an emetic; a decoction of the roots is limonoids 1 (mombasone) and 2 5'
Background:
The curcumin-C3 (cur-C3) complex obtained from Curcuma longa rhizome is a combination
of three curcuminoids, namely, curcumin, dimethoxycurcumin, and bisdemethoxycurcumin. Cur and curcuminoids
have been extensively researched for their wide range of therapeutic properties against inflammatory diseases,
diabetes, and cancer.
Objective:
In spite of their extensive medicinal properties, cur and curcuminoids have poor solubility and bioavailability
due to their hydrophobicity. This limitation can be overcome by complexing cur-C3 with natural cyclic oligosaccharides,
such as Cyclodextrin (CD).
Methods:
In this study, cur-C3 and CD (α, β) inclusion complexes (ICs) were prepared with different molar ratios
and characterized by nuclear magnetic resonance, Fourier transform infrared spectroscopy, X-ray diffraction, and
transmission electron microscopy.
Results:
The cur-C3 cyclodextrin ICs showed an increased entrapment efficiency of 97.8% and improved antioxidant
activity compared to cur and can be used as an antioxidant to reduce cancer-related oxidative stress. Additionally, α-
CD ICs of curcumin-C3 caused an increase in growth inhibition of Staphylococcus aureus.
Conclusion:
Our findings suggest that both α- and β-CDs are suitable carriers for cur-C3 and can be used as an effective
treatment for cancer-associated oxidative stress and as a preventive treatment for nosocomial infections and
pneumonia.
Nilotin [1], a new limonoid, has been isolated from the rootbark of Turraea nilotica and its structure established by spectroscopic methods. It displayed significant activity as an antifeedant against larvae of the Colorado potato beetle, Leptinotarsa decemlineata.
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