HighlightsCCR6+ T helper (Th) cells dominate the cerebrospinal fluid (CSF) in MS.CCR6+ Th17 cells are very rare.The dominant CCR6+ T cell subset secretes IFNγ and is elevated in MS CSF.The encephalitogenic cytokine GM-CSF is also secreted by these cells.GM-CSF-only secreting Th cells, also accumulate in the CSF especially in MS.
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