The metabotropic glutamate receptor 1 (mGluR1) is abundantly expressed in the mammalian central nervous system, where it regulates intracellular calcium homeostasis in response to excitatory signaling. Here, we describe heterozygous dominant mutations in GRM1, which encodes mGluR1, that are associated with distinct disease phenotypes: gain-of-function missense mutations, linked in two different families to adult-onset cerebellar ataxia, and a de novo truncation mutation resulting in a dominant-negative effect that is associated with juvenile-onset ataxia and intellectual disability. Crucially, the gain-of-function mutations could be pharmacologically modulated in vitro using an existing FDA-approved drug, Nitazoxanide, suggesting a possible avenue for treatment, which is currently unavailable for ataxias.

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The ancient surface of Mars is dominated by degraded impact craters with reduced or eliminated rim relief. Some degraded craters have an inlet valley, while many remain fluvially isolated. Despite controlling Martian fluvial connectivity, few constraints exist on why some—but not all—degraded craters possess inlets. We compared a suite of properties around degraded Martian craters with and without inlets to ascertain what topographic and hydrologic factors influenced inlet formation. Slope and surface roughness are similar, but topographic inset within the catchment, drainage density, and potential contributing areas diverge for breached and non‐breached craters. We suggest that the importance of basin hydrology‐related factors over topographic factors is the result of the former less frequently surpassing inlet incision thresholds than the latter. We conclude that greater topographic inset (i.e., craters deeper within regional depressions) promoted higher discharge, and that inlet valley formation was ultimately controlled by Mars' crater‐dominated topography.