In premature infants, NCPAP was more effective at preventing intubation and ventilation within 72 hours of starting therapy when given via nasal masks compared with nasal prongs.
Most drugs prescribed to newborns are unlicensed or used for off-label reasons. Many infants, and the majority of preterm infants, admitted to our NICU received unlicensed and off-label drugs.
This study was registered with the EU clinical trials register before the first patient was enrolled (Eudract 2011-002962-19). (https://www.clinicaltrialsregister.eu).
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