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Coeliac disease is precipitated in susceptible subjects by ingestion ofwheat gluten or gluten related prolamins from some other cereals. The disease is strongly associated with certain HLA-DQ heterodimers, for example, DQ2 (DQal*0501,1*0201) in most patients and apparently DQ8 (DQox1*0301, 11*0302) in a small subset. Gluten specific T cell clones (TCC) from coeliac intestinal lesions were recently established and found to be mainly restricted by HLA-DQ2 or HLA-DQ8. Antigen induced production of cytokines was studied in 15 TCC from three patients, 10 being DQ2 and five DQ8 restricted. (Gut 1995; 37: 766-776)

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