Olfactory dysfunction is reported frequently in patients with coronavirus disease 2019. However, an effective treatment for this dysfunction is unknown. The present study evaluated carbamazepine as a treatment option for olfactory dysfunction based on its use in cases of neuralgia, especially of the V cranial nerve. The study included 10 patients with coronavirus disease with olfactory complaints who were part of a cohort of 172 coronavirus disease patients monitored for late neurological manifestations. Carbamazepine was administered for 11 weeks. The adverse effects reported were drowsiness (9/10) and dizziness (2/10); 9 of the 10 patients reported improved olfactory function after carbamazepine treatment. While the role of carbamazepine in the control of post-coronavirus disease olfactory dysfunction could not be confirmed in this study, the satisfactory response observed in most patients in this series suggests that further studies are warranted.
Objectives This study aimed to analyze cognitive impairment associated with long-term coronavirus disease 2019 (COVID-19) syndrome and its correlation with anxiety, depression, and fatigue in patients infected with severe acute respiratory syndrome coronavirus. Methods This was a cross-sectional study of 127 patients with COVID-19. Tests to screen for neuropsychiatric symptoms included the Fatigue Severity Scale, Mini-Mental State Exam 2 (MMSE-2), Symbol Digit Modalities Test (SDMT), and Hospital Anxiety and Depression Scale. Results In cognitive tests, SDMT was abnormal in 22%, being more sensitive than MMSE-2 to detect cognitive changes. Furthermore, although manifestations such as fatigue, depression, and anxiety were frequent in the post-COVID-19 phase, these 3 conditions, known to contribute to cognitive impairment, were slightly correlated with worse performance on the rapid screening tests. Conclusions In patients with mild COVID-19 and cognitive complaints, SDMT helped to confirm disturbances in the attention domain and processing speed.
RESUMOO estudo tem por objetivo avaliar a capacidade civil de idosos com déficit cognitivo na direção veicular. Embora os idosos tenham direito a gozar de sua Capacidade Civil, a demência é uma doença comum no envelhecimento, que o impossibilita realizar diversas atividades, antes rotineira, como a condução veicular. Para tanto, buscou-se analisar o comportamento do idoso com demência, e os principais instrumentos para o reconhecimento da doença. A pesquisa avalia os aspectos neuropsicológicos, através dos instrumentos utilizados para reconhecimento, visto que os motoristas com déficit cognitivo estão mais propensos a direção perigosa. O método utilizado nesta pesquisa foi o levantamento bibliográfico, realizado em diversos bancos de dados e alguns portais oficiais da internet, utilizando-se de palavras-chaves referentes ao tema. Como resultados, a pesquisa revela, que a demência é um fator incapacitante, que compromete a Capacidade Civil do idoso, devido ao perigo constante. Logo, o estudo da Capacidade Civil mostra a importância do monitoramento das condições neuropsicológicas dos idosos junto a direção veicular. Palavras-chave: avaliação neuropsicológica, capacidade civil, demência, direção perigosa.
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