A virus minimally contains a nucleic acid genome packaged by a protein coat. The genome and capsid together are known as the nucleocapsid, which has an envelope containing a lipid bilayer (mainly phospholipids) originating from host cell membranes. The viral envelope has transmembrane proteins that are usually glycoproteins. The proteins in the envelope bind to host cell receptors, promoting membrane fusion and viral entry into the cell. Virus-infected host cells exhibit marked increases in glutamine utilization and metabolism. Glutamine metabolism generates ATP and precursors for the synthesis of macromolecules to assemble progeny viruses. Some compounds derived from glutamine are used in the synthesis of purines and pyrimidines. These latter compounds are precursors for the synthesis of nucleotides. Inhibitors of glutamine transport and metabolism are potential candidate antiviral drugs. Glutamine is also an essential nutrient for the functions of leukocytes (lymphocyte, macrophage, and neutrophil), including those in virus-infected patients. The increased glutamine requirement for immune cell functions occurs concomitantly with the high glutamine utilization by host cells in virus-infected patients. The development of antiviral drugs that target glutamine metabolism must then be specifically directed at virus-infected host cells to avoid negative effects on immune functions. Therefore, the aim of this review was to describe the landscape of cellular glutamine metabolism to search for potential candidates to inhibit glutamine transport or glutamine metabolism.
We determined the prevalence of metabolic syndrome (MetS) among military police officers (MPOs) from the radio patrol program of the Military Police of Sao Paulo State (PMESP). Towards this goal, we analyzed the following characteristics: shift duty (daytime or nighttime patrol), service length in the PMESP, education level attained, weekly alcohol consumption, smoking, and physical activity of 93 MPOs. The MPO groups were created based on work shift [daytime (n=48) or nighttime (n=45)], and years of MPO experience [≤3 years (n=48) or ≥10 years (n=45)]. The overall prevalence of MetS among the 93 MPOs was 43%. There was a higher prevalence of MetS in the group with ≥ten years (53.3%) than that with ≤three years (33.3%); so, 1,6 times higher. The more prevalent MetS indicators (n=93) included waist circumference (76.3%), hypertension (55.9%), reduced plasma HDL-cholesterol levels (44%), hypertriglyceridemia (32.2%), and hyperglycemia (20.4%). Greater waist circumference, hypertension, hypertriglyceridemia, higher glycated hemoglobin A1c (HbA1c) levels, and MetS itself were associated with the service length (i.e., ≥ten years). The work shift was not associated with any MetS indicator. Those who were overweight or obese were 2.2. times more likely to develop MetS. Hypertriglyceridemia, the best indicator of the MetS, increased the chance of developing MetS by 16 times. Conclusion: MPOs exhibit a high prevalence of MetS, associated with the years of service and age.
We evaluated the working number steps (STEPS) of 25 military police officers (MPOs: day shift n = 14 and night shift n = 11) from the Military Police of São Paulo State (PMESP) while patrolling São Paulo city center and its association with metabolic syndrome (MetS) indicators. The participants' body composition and anthropometric parameters: body mass index (BMI), fat-free mass (FFM), skeletal muscle mass (SMM) and clinical and laboratory data: systolic (SBP) and diastolic (DBP) blood pressure, and fasting plasma levels of glucose, glycated hemoglobin A1c (HbA1c), insulin, HDL-cholesterol, triacylglycerol (TG), and C-reactive protein (CRP) were also measured. According to the number of steps taken during the daily 12 h working period, the MPOs were divided into three groups: 600-2,000, 2,001-8,000, and >8,000 steps. On average, each participant took 5169 ± 614 steps per 12 h shift. While MPOs from the night shift walked 25% more than the day shift (6188±1069 vs. 4367±664), this difference was not statistically significant. Notably, the BMI, FFM (13.4%), SMM (14.5%), plasma HDL-cholesterol levels (32.2%), and DBP (19.1%) were significantly higher in group 1 compared to the other two groups. Furthermore, reduced physical activity, age, BMI, and tenure at PMESP were associated with increased MetS indicators. Overall, MPOs performing less than 2,000 steps per shift presented marked changes in body composition and plasma measurements and a higher MetS prevalence (64%) than those who were more physically active.
This study sought to identify monocyte alterations from septic patients after hospital discharge by evaluating gene expression of inflammatory mediators and monocyte polarization markers. It was hypothesized that sepsis reprograms the inflammatory state of monocytes, causing effects that persist after hospital discharge and influencing patient outcomes. DESIGN:The gene expression patterns of inflammatory receptors, M1 and M2 macrophage polarization markers, NLRP3 inflammasome components, and proand anti-inflammatory cytokines in monocytes were assessed.
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