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Light microscopy ISD is a suitable index of GERD. Alterations of intercellular glycoconjugates are likely to have a role in the genesis of ISD and GERD.

Highlights UGIB has a prevalence of 0.47% in non-ICU COVID-19 patients and peptic disease is the most common finding. Half of patients were managed conservatively or with delayed endoscopy. This is the first report that evaluates incidence of UGIB in COVID-19 patients. Conservative management and delayed endoscopy could be a successful option in patients with significant respiratory impairment.