Arrhythmia is often detected in cancer patient, from single ventricular premature contractions to sustained ventricular tachycardia, life threatening ventricular fibrillation and sudden cardiac death. Oncology per se, aggressive anticancer treatment, both chemotherapy and radiation and basic cardiac conditions are main causative factors for tachyarrhythmia. In this review we summarize evidence of arrhythmia and emphasize the importance of cardiac monitoring for the early diagnosis, intervention and surveillance of those patients more susceptible to develop proarrhythmia. Oncologists should be fully aware of arrhythmia and the close collaboration between cardiologists and oncologists would result in a better cardiovascular assessment, risk stratification, cardiac monitoring and treatment.
Objective: To study the effect of intense physical exertion on the normal physiology of the left ventricle (LV).Material and Methods. 146 professional athletes underwent a non-invasive assessment of LV systolic deformity in various directions. As a control group, 22 bowling athletes were surveyed.Results. In cyclists, eccentric hypertrophy of the LV myocardium was detected in 31.7% of men and in 29.5% of women. The values of global longitudinal strain were below 18% in male athletes from the cycling-BMX and cycling-highway groups (17.70±2.40% and 17.50±2.39%, respectively). Indicators of circular apical and circular global deformation were significantly lower in the group of cycling-BMX (men) compared with the corresponding values in the bowling group (14.50±6.23% and 14.70±6.42%; 18.40±6.32% and 16.90±6.43%, respectively, p<0.01).
The performed study is devoted to the analysis of the effect of mesodiencephalic (MDM) therapy and normobaric hypoxia on the carbohydrate and lipid metabolism in the complex rehabilitation of patients with post-COVID syndrome. It has been shown that the metabolic potential of MDM therapy is more pronounced than that of hypoxic training, and with the combined use of these factors, the therapeutic effect is significantly enhanced. This phenomenon is explained by the involvement of the body in the response reaction to the effects of various functional systems, while a supraaditive type of synergistic interaction of physical factors is noted. It is proved that one of the factors limiting therapeutic effect is the presence of metabolic syndrome in patients. The use of MDM therapy makes it possible to increase the sensitivity of the body to the action of insulin, while the regression of the insulin resistance index correlates with an improvement in well-being. At the same time, the formation of adaptive type reactions is recorded, which is confirmed by an increase in the activity of glucocorticoids. The combined use of physiofactors helps to reduce the manifestations of oxidative stress.
The performed study is devoted to the analysis of the initial clinical and functional state of patients with post-COVID syndrome and to the evaluation of the effectiveness of rehabilitation measures, supplemented by the course use of MDM therapy and interval hypoxic training. It is shown that, despite the various clinical manifestations of post-COVID syndrome, the severity of complaints and indicators of the objective status of patients are largely determined by the presence of concomitant pathology that reduces the functional reserves of the body. The results obtained allow us to conclude that the additional course use of MDM therapy and the technique of interval hypoxic training increases the effectiveness of patients» rehabilitation. The complex application of these factors makes it possible to speak about the formation of functional potentiation, which determines the strategy for achieving high final efficiency of directed rehabilitation, opening up new opportunities for optimizing the recovery process. The basis of the supra-additive type of synergistic interaction of physiofactors is the complementation of subeffective shifts in the estimated parameters induced by each of the factors, as well as the formation of functional cumulation, in which the cumulative corrective effect is the result of epigenetic regulation of adaptation process.
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