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Abciximab-coated stent implantation was safe and effective without stent thrombosis in AMI patients.

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α-LA feeding and α-LA coated stents inhibit neointimal hyperplasia in porcine ISR, possibly through inhibiting the activation of NF-κb pathway and proliferation of PVSMC.

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TCA and TCALA are more effective to reduce neointimal hyperplasia compared to TC. Moreover, fibrin and inflammation scores are significantly lower in TCA and TCALA than BES in porcine coronary restenosis model.

Nitrogen doped-TiO 2 thin film was deposited by plasma enhanced chemical vapour deposition (PECVD) process and its applicability as a drug-binding matrix was investigated in the preparation of drug eluting stents. N-TiO 2 film was deposited at 5 W and uniformly covered metallic stent surfaces. Films showed excellent mechanical stability and good adhesion. Alpha lipoic acid, heparin, and abciximab could then be grafted onto the N-TiO 2 film through ester bond formation after water plasma modification of the films' surfaces. Drug-grafted N-TiO 2 films showed smooth surfaces and good blood compatibility in in vitro platelet adhesion tests. The films maintained uniform coverings, without peeling, even after expansion by a balloon catheter. Grafted-heparin and abciximab could be released continuously for three weeks from drug-grafted N-TiO 2 stents in in vitro drug release test. Such immunosuppressive and antiproliferative drug-grafted N-TiO 2 film is expected to minimize potential problems related to organic polymers and the risk of direct contact of a bare metal surface with a blood vessel. Hence, the N-TiO 2 films prepared in this study are promising alternatives to organic polymers for the preparation of drug-eluting stents.