Oxaliplatin and gemcitabine chemotherapy seems to be effective with a favorable safety profile in first-line chemotherapy of advanced biliary tract cancers.

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(1) Background: Breast cancer (BC) is the most prevalent malignancy in women. High cancer-related psychological distress levels have been observed in BC patients, with a potentially relevant impact on disease management, compliance with disease treatments, and everyday life activities and relationships. This work evaluated the effectiveness of three individual cognitive–behavioral therapy psychoeducational sessions versus a self-managed informative guide with individual counseling sessions without specific psychological treatment. (2) Methods: the intervention group received three individual 50-min sessions of psychoeducational training, and the control group received a self-managed informative guide with individual counseling sessions without any kind of psychological treatment. The Hospital Anxiety Depression Scale (HADS), the Distress Thermometer (DT), and the EORTC (European Organization for Research and Treatment of Cancer) QLQ-C30 were administered at baseline and two months after study inclusion. (3) Results: A total of 60 participants were included in the study (intervention group: 30, control group: 30). Significant improvements were observed in both groups after two months (p < 0.05), but no statistically significant differences emerged between groups. (4) Conclusions: Psychoeducational interventions and CBT help BC patients manage disease-related fear and distress, allowing them to achieve a good quality of life.

We report a clinical case of Merkel cell carcinoma treated withlanreotide.An 86-year-old male patient with comorbidity (chronic atrial fibrillation, heart failure, COPD, chronic kidney disease, history of noninvasive muscle bladder cancer treated from 2004 with TURV and intravesical instillations with BCG), presented in July 2012 a subcutaneous neoformation of the side of the left knee for which it was subjected to surgical excision.The macroscopic examination described "cutaneous lozenge of 6.2 × 5 × 1 cm centered by a formation of 4.3 × 4 cm partly covered by intact skin, partly ulcerated and covered with crusts, irregular, and shaded margins; when cut, the neoformation appears to consist of a whitish compact tissue organized in nodules separated by fibrous septa; negative resection margins". The microscopic examination documented "overall picture referable to Merkel cell tumor (CK20+, NSE+, CD20−, CD3−); the lesion reaches one of the lateral margins but respects the other margins and the bottom of the excision (minimum distance from the bottom 0.4 mm). Merkel pT2-Nx-Mx cell tumor". At the full-body CT of staging there were no documented secondary lesions. A PET scan was performed: "presence of a hyperaccumulation area located in the left inguinal region, of lymph node relevance characterized by two contiguous sub-centimetric nodules with SUVmax 10.5 suspected for secondary, vital, high metabolic heteroplastic tissue. Furthermore, at the level of the subcutaneous region of the lateral aspect of the left knee, the presence of a further area of metabolic hyperactivity with a SUVmax 3.8 suspected due to

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