The following review focuses on how the study of anatomy in Japan has evolved throughout the centuries; specifically, we investigate anatomical knowledge during the primitive, ancient, feudal, and early modern periods of Japanese history. Early vague and mythical anatomical concepts derived from China prevailed for many centuries in Japan. Kajiwara wrote one of the earliest anatomical works in 1302. As a science, anatomy was the first basic science to be established in Japan, beginning simplistically during the 1600s and flourishing more recently with the onset of Meiji Restoration. As a result, Japan has produced several of the most influential anatomists of the 20th century, including Buntaro Adachi, who added detail to our knowledge of the vascular system and its variations; and Sunao Tawara, who discovered the atrioventricular node. Herein, we discuss the ways in which Japan has added to and promoted the anatomical sciences.
Cholestasis is a general feature of intrahepatic or extrahepatic biliary obstruction by various mechanisms including cirrhosis, stricture, choledocholithiasis, hepatitis, and neoplasms. Neoplasms can directly impinge on the hepatobiliary tree resulting in bile stasis. Stauffer’s syndrome is another variant of this neoplastic process that can cause cholestasis and liver enzyme elevation without any direct hepatobiliary obstruction, and is thus categorized as a paraneoplastic syndrome of unclear pathophysiology. We report a first case of metastatic prostate adenocarcinoma with features of Stauffer’s syndrome that reversed completely on androgen deprivation therapy. This is in contrast to a previously reported case of Stauffer’s syndrome due to metastatic prostate adenocarcinoma, which reversed partially to androgen deprivation therapy. Our case demonstrates the importance of early recognition of Stauffer’s syndrome and underlying neoplasms in patients who present with cholestasis without clear evidence of intrahepatic or extrahepatic biliary obstruction, which may lead to early initiation of treatment.
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<p>Although females in human and the great ape populations reach the end of fertility at similar ages (approximately 45 years), female humans often live well beyond their post-fertile years, while female primates typically die before or shortly after the end of fertility. The grandmother hypothesis proposes that the care-giving role provided by post-fertile females contributed to the evolution of longevity in human populations. When post-fertile females provide care for weaned infants, mothers are able to have their next baby sooner without compromising the chances of survival of their previous offspring. Thus, the post-menopausal longevity that is unique to human populations may be an evolutionary adaptation. In this work, we construct, simulate, and analyze an ordinary differential equations mathematical model to study the grandmother hypothesis. Our model describes the passage of the individuals of a population through five life stages in the cases with and without grandmothering. We demonstrate via numerical simulation of the mathematical model that grandmothering care is sufficient to significantly increase adult life expectancy. We also investigate the relationship between the number of weaned infants that a post-fertile female can care for at a given time and the steady-state age distributions of a population.</p>
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