Over the last decade the discourse of responsible innovation (RI) has become a significant feature of debates concerning the relationships between science, innovation and society in the fields of biosciences and biotechnologies. We document how this discourse has evolved over the period 2014-2019 at a Synthetic Biology Research Centre hosted within a University in the UK (BrisSynBio). We describe how an approach to RI has evolved to include but go beyond public engagement, by encouraging practices aimed at anticipation, reflexivity and deliberation in sometimes creative and innovative ways. We describe how the Centre has struggled to capture the impacts of RI interventions on the everyday practices and behaviours of scientists and the outcomes of their work. The study reveals the importance of leadership, creativity, innovation, institutional support, openness to change and mechanisms of capturing impact for successful RI institutionalisation.

It is increasingly suggested that shortages in the supply chain for human blood could be met by the development of techniques to manufacture human blood ex vivo. These techniques fall broadly under the umbrella of synthetic biology. We examine the biopolitical context surrounding the ex vivo culture of red blood cells through the linked concepts of alienation, immunity, bio-value and biosecuritization. We engage with diverse meanings of synthetic blood, and questions about how the discourses of biosecurity and privatization of risk are linked to claims that the technology will address unmet needs and promote social justice. Through our discussion we contrast communitarian ideas that culturing red blood cells 'extends the gift' of adult blood donation with understandings of the immunitary logics that underpin the cord-blood economy.

There is a growing recognition within cognitive enhancement and neuroethics debates of the need for greater emphasis on cognitive artefacts. This paper aims to contribute to this broadening and expansion of the cognitive-enhancement and neuroethics debates by focusing on a particular form of relation or coupling between humans and cognitive artefacts: interaction-dominance. We argue that interaction-dominance as an emergent property of some human-cognitive artefact relations has important implications for understanding the attribution and distribution of causal and other forms of responsibility as well as agency relating to the actions of human-cognitive artefact couplings. Interaction-dominance is both indicated and constituted by the phenomenon of “pink noise”. Understanding the role of noise in this regard will establish a necessary theoretical groundwork for approaching the ethical and political dimensions of relations between human cognition and digital cognitive artefacts. We argue that pink noise in this context plays a salient role in the practical, ethical, and political evaluation of coupling relations between humans and cognitive artefacts, and subsequently in the responsible innovation of cognitive artefacts and human-artefact interfaces.