Quinolines and their derivatives have always been promising leads for drug discovery, material applications and designing new catalysts. In the past decade, C(sp 3 )-H functionalization of 2-methyl azaarenes, particularly 2-methyl quinol- [a]
ACYLATIONAlmost the early report of C(sp 3 )-H functionalization of 2methyl quinoline was performed by treating with esters using sodamide or potassium amide as the base. This reaction followed the nucleophilic substitution at the sp 2 center of the ester by the benzylic carbanion which was formed by the base treatment (Scheme 2). A total of 15 compounds were made using this method with the yields ranging from 14-62 %. [11] After a couple of years, another report [12] appeared for this transformation, where 2-methyl quinoline and esters were reacted in the presence of phenyllithium to give corresponding acylated quinolines in 36-80 % yields. Later in 1974, J. F. Wolfe reported another approach by treating 2-methyl quinoline with esters refluxed in dimethoxyethane (DME) using sodium hydride for 1-48 h to obtain the corresponding acylated quinolines in 44-98 % yields. [13] Scheme 2.
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In this contribution, we demonstrate the synthesis of gold nanoparticles (AuNPs) using an entirely green chemistry process. Justicia adhatoda leaf extract used as a bioreductant for the synthesis of AuNPs and its particle sizes are controlled by altering the concentration of metal salt. The optical and morphological properties were studied. We report on the synthesis of stable spherical, well-dispersed colloidal AuNPs (27.1, 33.3 and 46.8 nm) by efficient reducing agents with its mechanisms. The X-ray diffraction analysis also confirmed the obtained sizes of AuNPs with its crystallite size (20.2, 40.1 and 40.3 nm). Catalytic activity of fabricated AuNPs are also examined on the degradation of organic dyes.
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