In this review we highlight the possible pathophysiological mechanisms implicated in the observed postoperative lung dysfunction.

Therapeutic angiogenesis is based on the premise that the development of new blood vessels can be augmented by exogenous administration of the appropriate growth factors. Over the last years, successful preclinical studies and promising results of early clinical trials have created great excitement about the potential of therapeutic angiogenesis for patients with advanced ischemic heart disease. The authors provide an overview of the biology of angiogenesis, the basic characteristics of angiogenic factors, and the different routes of their delivery. They discuss experimental studies in animal models of myocardial ischemia and outline available clinical studies on therapeutic angiogenesis for myocardial ischemia. Related safety issues are also addressed followed by a critical perspective about the future of proangiogenic therapies for ischemic cardiovascular disorders. Despite the established proof of concept and reasonable safety, however, results of the latest trials on therapeutic angiogenesis for myocardial ischemia have provided inconsistent results and the definite means of inducing clinically useful therapeutic angiogenesis remain elusive. More studies are required to gain further insights into the biology of angiogenesis and address pharmacological limitations of current approaches of angiogenic therapy. The authors hope and envisage that in the not-too-distant future, these investigative efforts will lead to important new strategies for treatment of myocardial ischemic syndromes. Means of non-invasive individualized pharmacological therapeutic neovascularization may be the next major advance in the treatment of ischaemic heart disease.

Background: We evaluated the ability of 3D-CT and virtual bronchoscopy to estimate trachea stenosis in comparison to conventional axial CT and fiberoptic bronchoscopy, with a view to assist thoracic surgeons in depicting the anatomical characteristics of tracheal strictures.

Objectives The purpose of the study was to investigate the smoking habits of medical and other students and to explore the most important factors associated with students' smoking. Methods University students were surveyed in late spring 2006 regarding their smoking status and additional healthand behavior-related characteristics. Results A total of 1205 (269 medical and 936 nonmedical) students participated in the study. Of these 47% reported being current smokers (35% among medical students), and 30% of the smokers had already started smoking at the age of 16 years. Smokers reported a significantly higher prevalence of cough and respiratory infections and a decrease in physical fitness. The most important factor associated with smoking prevalence was friendship with smokers and maternal smoking. A better knowledge of harmful effects showed a strong association with nonsmokers. Although nonmedical students exhibited a greater possibility to be a smoker, awareness of harmful effects among medical students was not as significant as factor against smoking compared with among nonmedical students.Conclusions This study shows that smoking prevalence among medical and other students in Greece is extremely high. A lack of effective education against smoking in medical students was evident and this underlines the need to identify the factors to be included in planning effective antismoking programs.

Our results indicate that fibrin glue is a safe sealing material for lung PLB and serves to decrease the incidence and, in particular, the severity of pneumothorax, especially in high-risk patients.