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The precise failure mechanisms of bone implants are still incompletely understood. Micro-computed tomography in combination with finite element analysis appears to be a potent methodology to determine the mechanical stability of bone-implant constructs. To assess this microstructural finite element (µFE) analysis approach, pull-out tests were designed and conducted on ten sheep vertebral bodies into which orthopedic screws were inserted. µFE models of the same bone-implant constructs were then built and solved, using a large-scale linear FE-solver. µFE calculated pull-out strength correlated highly with the experimentally measured pull-out strength (r 2 = 0.87) thereby statistically supporting the µFE approach. These results suggest that bone-implant constructs can be analyzed using µFE in a detailed and unprecedented way. This could potentially facilitate the development of future implant designs leading to novel and improved fracture fixation methods.Keywords Bone-implant competence · Micro-finite element analysis (µFEA) · Bone microstructure · Peri-implant bone quality · Mechanical testing · Pull-out strength

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