In a series of 404 adult soft tissue sarcomas, analyzed by array-CGH, we have observed in approximately 10% of them a genomic amplification of either chromosome bands 11q22 or 3p12. These two amplicons likely target the YAP1 and VGLL3 genes, respectively. Both genes encode proteins that are cofactors of the TEAD family of transcription factors. Very good correlations between amplification and expression levels were observed. Welch test analyses of transcriptome data demonstrate that tumors with amplicons share a large set of upregulated and downregulated genes. Inhibition of YAP1 and VGLL3 in cell lines with these amplifications/overexpressions leads to similar phenotypes: decrease of proliferation rate, and to a lesser extent decrease of migration properties. These data, and the fact that these amplicons are observed either in de-differentiated liposarcomas or in undifferentiated pleomorphic sarcomas, suggest that these genetics events could be involved in oncogenesis and progression of soft tissue sarcomas.
Cisapride is a safe, well tolerated prokinetic agent that improves the esophageal clearance of refluxed gastric acid in children under the age of 2 years.
Occupational health can be strongly influenced by the indoor environment as people spend 90% of their time indoors. Although indoor air quality (IAQ) is not typically monitored, IAQ parameters could be in many instances very different from those defined as healthy values. Particulate matter (PM), a complex mixture of solid and liquid particles of organic and inorganic substances suspended in the air, is considered the pollutant that affects more people. The most health-damaging particles are the ≤PM10 (diameter of 10 microns or less), which can penetrate and lodge deep inside the lungs, contributing to the risk of developing cardiovascular and respiratory diseases, as well as of lung cancer. This paper presents an Internet of Things (IoT) system for real-time PM monitoring named iDust. This system is based on a WEMOS D1 mini microcontroller and a PMS5003 PM sensor that incorporates scattering principle to measure the value of particles suspended in the air (PM10, PM2.5, and PM1.0). Through a Web dashboard for data visualization and remote notifications, the building manager can plan interventions for enhanced IAQ and ambient assisted living (AAL). Compared to other solutions the iDust is based on open-source technologies, providing a total Wi-Fi system, with several advantages such as its modularity, scalability, low cost, and easy installation. The results obtained are very promising, representing a meaningful tool on the contribution to IAQ and occupational health.
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