Screening for and treating asymptomatic bacteriuria are common in KTRs despite uncertainties around the benefits and harms. In an era of antimicrobial resistance, further studies are needed to address the diagnosis and management of asymptomatic bacteriuria in these patients.
BackgroundRenal dysfunction is a major determinant of the Model of End-stage Liver Disease (MELD)
score. The implementation of the MELD score has shifted allocation of livers to patients
with renal dysfunction.ObjectivesThe aim of our study was the assessment of estimated Glomerular Filtration Rate (eGFR)
by the Modification of Diet in Renal Disease 4 (MDRD4) method in patients with HBV
chronic hepatitis, HCV chronic hepatitis, and cirrhosis (CH) caused by these viruses to
detect any differences in renal function among these diseases.Patients and MethodsWe performed a cross-sectional analysis of all consecutive patients with HBV chronic
hepatitis, HCV chronic hepatitis, and cirrhosis caused by these viruses hospitalized
during a 4 year period in the Gastroenterology and Hepatology department of the
Emergency County Hospital Timisoara, Romania. The eGFR was assessed by the MDRD4 method.
Statistical analysis (unpaired t-test, ANOVA, Chi Square test) was performed using
OpenEpi 2.3.1.ResultsHBV chronic hepatitis, HCV chronic hepatitis, and cirrhosis secondary to these viruses
were associated with a reduction of the GFR. The eGFR was higher in patients with HBV
chronic hepatitis than in patients with HCV chronic hepatitis (P < 0.001).
Patients with cirrhosis secondary to HBV infection had a higher eGFR than patients with
cirrhosis secondary to HCV (P = 0.01). The eGFR of patients with HCV chronic hepatitis
was higher than the eGFR of patients with cirrhosis due to this virus (P <
0.001).ConclusionsFunctional renal impairment in diseases caused by HCV was more important than in
diseases caused by HBV. The eGFR was statistically lower in cirrhosis secondary to HCV
than in HCV chronic hepatitis.
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