The Catalytic Site Atlas (CSA) provides catalytic residue annotation for enzymes in the Protein Data Bank. It is available online at http://www.ebi.ac.uk/ thornton-srv/databases/CSA. The database consists of two types of annotated site: an original handannotated set containing information extracted from the primary literature, using de®ned criteria to assign catalytic residues, and an additional homologous set, containing annotations inferred by PSI-BLAST and sequence alignment to one of the original set. The CSA can be queried via Swiss-Prot identi®er and EC number, as well as by PDB code. CSA Version 1.0 contains 177 original handannotated entries and 2608 homologous entries, and covers~30% of all EC numbers found in PDB. The CSA will be updated on a monthly basis to include homologous sites found in new PDBs, and new hand-annotated enzymes as and when their annotatation is completed.
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