The treatment during the embryonic preimplantation phase of Wistar rats with the Pradosia huberi extract did not interfere with the water and feed consumption, as well as upon the body-weight gain. However, it has expressed a decrease of the uterine implant number, followed by the preimplantation losses at all applied doses (1.22, 6.1, and 30.5 mg/kg), and the number of embryonic resorptions in the two highest doses (6.1 and 30.5 mg/kg). After the organ weighing (hypophysis, ovaries, and uterus), only the relative weight of the hypophysis was raised at the different doses (1.22, 6.1, and 30.5 mg/kg). It was concluded that the hydroalcoholic extract of Pradosia huberi compromises the reproductive ability during the embryonic preimplantation phase, suggesting a possible toxic effect upon the reproductive system of Wistar rats.
This study aims to analyze the temporal distribution of human (HVL) and canine visceral leishmaniasis (CVL) in the state of Paraíba between 2012 and 2017, by Intermediate and Immediate Geographic Region (GR). As an ecological study with a quantitative approach, data were collected in the LACEN PB database; Dra. Telma Lobo Central Public Health Laboratory, Paraíba; and refer to positive cases of HVL and CVL presented in the state in the period under study. Poisson Regression Modeling was used to quantify the average number of cases from one year to another. The results revealed that the immediate GRs of Mamanguape - Rio Tinto, Campina Grande, and Cajazeiras present a statistically significant increasing trend in the average number of HVL cases. The immediate GRs of Campina Grande, Patos, Cuité - Nova Floresta, Itaporanga, and João Pessoa revealed a significant increase in the average number of CVL cases during the period analyzed. The need for reorganization of disease control operations and preventive actions was confirmed, especially in those regions identified with growth.
Objetivo: analisar os fatores que influenciam a ocorrência da Leishmaniose Visceral Humana no estado da Paraíba, Brasil. Métodos: estudo ecológico, desenvolvido com os dados de 2012 a 2017, coletados em um laboratório de referência no estado e no Atlas do Desenvolvimento Humano no Brasil. A análise dos dados foi pelo modelo de regressão binomial, correlação de Pearson e Teste Kolmogorov-Smirnov. Resultados: foram confirmados 327 casos de leishmaniose visceral humana e 6.353 casos de leishmaniose visceral canina. Os principais indicadores municipais possuem uma relação significativa com o número de casos da doença no estado, e forte relação com número de casos positivos para Leishmaniose Visceral Humana. Conclusão: o modelo pode ser utilizado como referência para analisar a distribuição de casos da leishmaniose visceral humana e os possíveis fatores que influenciam na sua ocorrência,fornecendo aos gestores municipais mais uma alternativa de realização de medidas de controle/prevenção da doença, envolvendo diversos setores.
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