Deep neural networks (DNN) have shown promises in the lesion segmentation of multiple sclerosis (MS) from multicontrast MRI including T1, T2, proton density (PD) and FLAIR sequences. However, one challenge in deploying such networks into clinical practice is the variability of imaging protocols, which often differ from the training dataset as certain MRI sequences may be unavailable or unusable. Therefore, trained networks need to adapt to practical situations when imaging protocols are different in deployment. In this paper, we propose a DNN-based MS lesion segmentation framework with a novel technique called sequence dropout which can adapt to various combinations of input MRI sequences during deployment and achieve the maximal possible performance from the given input. In addition, with this framework, we studied the quantitative impact of each MRI sequence on the MS lesion segmentation task without training separate networks. Experiments were performed using the IEEE ISBI 2015 Longitudinal MS Lesion Challenge dataset and our method is currently ranked 2 nd with a Dice similarity coefficient of 0.684. Furthermore, we showed our network achieved the maximal possible performance when one sequence is unavailable during deployment by comparing with separate networks trained on the corresponding input MRI sequences. In particular, we discovered T1 and PD have minor impact on segmentation performance while FLAIR is the predominant sequence. Experiments with multiple missing sequences were also performed and showed the robustness of our network.Index Terms-Multi-Contrast MRI, multiple sclerosis lesion segmentation, fully convolutional neural network
The optimization of full-scale biogas plant operation is of great importance to make biomass a competitive source of renewable energy. The implementation of innovative controi and optimization algorithms, such as Nonlinear Model Predictive Control, requires an online estimation of operating states of biogas plants. This state estimation allows for optimal control and operating decisions according to the actual state of a plant. In this paper such a state estimator is developed using a calibrated simulation model of a full-scale biogas plant, which is based on the Anaerobic Digestion Model N0.1. The use of advanced pattern recognition methods shows that model states can be predicted from basic online measurements such as biogas production, CH4 and CO2 content in the biogas, pH value and substrate feed volume of known substrates. The machine learning methods used are trained and evaluated using synthetic data created with the biogas plant model simulating over a wide range of possible plant operating regions. Results show that the operating state vector of the modelled anaerobic digestion process can be predicted with an overall accuracy of about 90%.This facilitates the application of state-based optimization and control algorithms on full-scale biogas plants and therefore fosters the production of eco-friendly energy from biomass.
With any strong cryptographic algorithm, such as the data encryption standard (DES), it is possible to devise protocols for . "authentication. One technique, which allows arbitrary, time-invar-.~I'iant quantities (such as encrypted keys and passwords) to be auj ; ..~ thenticated, is based upon a secret-cryptographic (master) key residing in a host processor. Each quantity to be authenticated has a corresponding precomputed test pattern. At any later time, the test pattern can be used together with the quantity to be authenticated to generate a nonsecret verification pattern. The verification pattern can in turn be used as the basis for accepting or rejecting the quantity to be authenticated.
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