A direct electrochemical oxidative cyclization of activated alkynes with diselenides or disulfides toward functionalized coumarins and quinolinones has been developed.
A novel and green route has been developed for the electrochemical synthesis of spiro[4.5]trienones through radical‐initiated dearomative spirocyclization of alkynes with diselenides. This metal‐free and oxidant‐free electrosynthesis reaction was performed in an undivided cell under mild conditions. A variety of selenation spiro[4.5]trienones products were prepared in moderate‐to‐good yields, showing a broad scope and functional group tolerance. Moreover, the developed continuous‐flow system combined with electrosynthesis possesses the potential to achieve scaled‐up reactions, overcoming the low efficiency of conventional electrochemical scaled‐up reactions.
An efficient and green electrochemical continuous flow approach has been developed for the synthesis of 4-(sulfonylmethyl)isoquinoline-1,3(2H,4H)-diones through sulfonylation of alkenes with sulfonylhydrazides. The reaction proceeds in a flow electrolytic cell...
A new and efficient method for the synthesis of C-3 dicarbonyl indoles via oxidative cross-coupling of styrenes with indoles under metal-free conditions has been developed. Moreover, a broad scope of C-3 dicarbonyl indoles in moderate to good yields were obtained, and a plausible mechanism is proposed based on control and isotope-labeling experiments.
A non‐oxidant and metal‐free strategy for synthesizing iso‐coumarin by using a continuous electrochemical microreactor to initiate an oxidative cyclization reaction of o‐(1‐alkynyl) benzoate and radicals. This efficient and clean continuous electrosynthesis method not only avoids the complicated gas protection operation and production of by‐products in the batch processes, but also help to overcome the difficulty that batch metal catalysis and electrocatalysis are difficult to scale up, and has the potential for pilot‐scale experiment.
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