A design methodology for micromixers is presented which systematically integrates computational fluid dynamics (CFD) with an optimization methodology based on the use of design of experiments (DOE), function approximation technique (FA) and multi-objective genetic algorithm (MOGA). The methodology allows the simultaneous investigation of the effect of geometric parameters on the mixing performance of micromixers whose design strategy is based fundamentally on the generation of chaotic advection. The methodology has been applied on a Staggered Herringbone Micromixer (SHM) at several Reynolds numbers. The geometric features of the SHM are optimized and their effects on mixing are evaluated. The degree of mixing and the pressure drop are the performance criteria to define the efficiency of the micromixer for different design requirements

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A 3-D configuration of a T-mixer is evaluated under normal operating conditions of the called convective micromixers. The design has been called 3-D T-mixer in our previous work [1] as it adopts a three-dimensional structure at the T-junction. This design feature has been found that it exerts a strong effect on the flow characteristics in the device downstream in the mixing channel. A numerical study has been carried out in the 3-D T-mixer and the typical T-mixer, being these modelled with equal dimensions of channel lengths and cross sections and operated with the same flow rates. The flow analysis in the 3-D T-mixer reveals the quick formation of vortical flow structures composed of intertwined fluid filaments which increase drastically the fluids interface to enhance mixing. The flow patterns in the mixing channel vary with Reynolds number (Re) in the range 100-500. This study shows that the 3-D T-mixer provides a significant enhancement of mixing and presents lower pressure loss and similar level of shear stress compared to a typical T-mixer, in the whole range of Re used to characterize the flow. It has a simple channel configuration which is easy to fabricate and effective for mixing of continuous fluid and potentially particles. The 3-D T-mixer is called to be tested and applied for improving the efficiency of systems which have a T-junction in their design and require fast mixing with high throughput

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