The use of trimethyl and dimethyl chlorosilanes and silazanes as silylating agents for organic chemicals is cited. Physical and chemical properties of commercially available silanes are given, and the chemistry of silylation is briefly described. Examples taken from the published literature are given where solubility and stability of organic materials are modified with these materials. In addition, silylating agents are a means of temporarily blocking organic functional groups containing active hydrogen. Several examples are given of the use of silylation as a process aid in the pharmaceutical industry, primarily in the synthesis of penicillins.
The syntheses and chemical properties of some 54 compounds are described, all having structural units including ==SiCCCN= with either methyl, phenyl, siloxy, alkoxy, or amino groups on silicon and H, alkyl, or phenyl groups on nitrogen. Thirteen of the compounds are novel substituted heterocyclic l-aza-2-silacyclopentanes and one is a l-aza-2-silacyclohexane.
The design and Performance of """Tc chelates that are used for brain perfusion SPECT imaging relates to their extraction efficiency by brain and their degree of cerebral retention. The influence of chelate structure on BBB penetration and intracellular trapping mechanisms are discussed.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.