We provide an overview of chemical transformations that proceed spontaneously, by mixing of initially solid reactants, and are accelerated and/or directed through gentle stimuli in the form of mild heating,...
We demonstrate catalytic organic synthesis by Resonant Acoustic Mixing (RAM): a mechanochemical methodology that does not require bulk solvent or milling media. Using as model reactions rutheniumcatalyzed ring-closing metathesis and copper-catalyzed sulfonamide-isocyanate coupling, RAM mechanosynthesis is shown to be faster, operationally simpler than conventional ball-milling, while also providing the first example of a mechanochemical strategy for rutheniumcatalyzed ene-yne metathesis. Reactions by RAM are readily and directly scaled-up without any significant changes in reaction conditions, as shown by the straightforward 200-fold scaling-up of the synthesis of the antidiabetic drug Tolbutamide, from hundreds of milligrams directly to 30 grams.
Mechanochemistry enables rapid access to boron imidazolate frameworks (BIFs), including the archetypal materials based on Li and Cu(I) nodes, as well as new, previously unexplored systems based on Ag(I) nodes....
Resonant Acoustic Mixing (RAM) offers a simple, efficient route for mechanochemical synthesis in the absence of milling media or bulk solvents. Here, we show the use of RAM to conduct...
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