The first observation of random laser action in a partially ordered, optically anisotropic nematic liquid crystal with long-range dielectric tensor fluctuations is reported. Above a given pump power the fluorescence curve collapses and the typical narrowing and explosion effect leads to discrete sharp peaks. The unexpected surviving of interference effects in recurrent multiple scattering provide the required optical feedback for lasing in nematics. Coherent backscattering of light waves in orientationally ordered nematic liquid crystals manifests a weak localization of light which strongly supports diffusive laser action in presence of gain medium. Intensity fluctuations of the speckle-like emission pattern indicate the typical spatio-temporal randomness of diffusive laser emission. A comparison of the laser action is reported for systems with different order degree: fully disordered semiconductor powders, self-ordered cholesterics and partially ordered nematic liquid crystals.
Mesoporous silica nanoparticles (MSNs) have been proposed as DNA and drug delivery carriers, as well as efficient tools for fluorescent cell tracking. The major limitation is that MSNs enter cells regardless of a target-specific functionalization. Here we show that non functionalized MSNs, synthesized using a PEG surfactant-based interfacial synthesis procedure, do not enter cells, while a highly specific, receptor mediated, cellular internalization of folic acid (FOL) grafted MSNs (MSN-FOL), occurs exclusively in folate receptor (FR) expressing cells. Neither the classical clathrin pathway nor macropinocytosis is involved in the MSN endocytic process, while fluorescent MSNs (MSN-FITC) enter cells through aspecific, caveolae-mediated, endocytosis. Moreover, internalized particles seem to be mostly exocytosed from cells within 96 h. Finally, cisplatin (Cp) loaded MSN-FOL were tested on cancerous FR-positive (HeLa) or normal FR-negative (HEK293) cells. A strong growth arrest was observed only in HeLa cells treated with MSN-FOL-Cp. The results presented here show that our mesoporous nanoparticles do not enter cells unless opportunely functionalized, suggesting that they could represent a promising vehicle for drug targeting applications.
Ferroelectrics (FEs) are materials of paramount importance with a wide diversity of applications. Herein, we propose a postsynthetic methodology for the smart implementation of ferroelectricity in chiral metal-organic frameworks (MOFs): following a single-crystal to single-crystal cation metathesis, the Ca counterions of a preformed chiral MOF of formula Ca{Cu[(S,S)-hismox](OH)}·212HO (1), where hismox is a chiral ligand derived from the natural amino acid l-histidine, are replaced by CHNH. The resulting compound, (CHNH){Cu[(S,S)-hismox](OH)}·178HO (2), retains the polar space group of 1 and is ferroelectric below 260 K. These results open a new synthetic avenue to enlarge the limited number of FE MOFs.
Distributed feedback microstructures play a fundamental role in confining and manipulating light to obtain lasing in media with gain. Here, we present an innovative array of organic, color-tunable microlasers which are intrinsically phase locked. Dye-doped helixed liquid crystals were embedded within periodic, polymeric microchannels sculptured by light through a single-step process. The helical superstructure was oriented along the microchannels; the lasing was observed along the same direction at the red edge of the stop band. Several physical and technological advantages arise from this engineered heterostructure: a high quality factor of the cavity, ultralow lasing threshold, and thermal and electric control of the lasing wavelength and emission intensity. This level of integration of guest-host systems, embedded in artificially patterned small sized structures, might lead to new photonic chip architectures.
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