Two hundred thirty-seven patients with cancer of the breast treated with radical mastectomy were reviewed. Coefficients of correlation between patient's and doctor's delay vs. survival were not significant at p smaller than 0.05. No significant relationship between delay and time of recurrence was found.
Pathological diagnosis of drowning remains a challenge for forensic science, because of a lack of pathognomonic findings. We analyzed microbiota and surfactant protein in the lungs for a novel diagnosis of drowning. All rats were divided into drowning, postmortem submersion, and control groups. The water, lungs, closed organs (kidney and liver), and cardiac blood in rats were assayed by targeting 16S ribosomal RNA of Miseq sequencing. Lung samples were analyzed by immunohistochemical staining for surfactant protein A. The closed organs and cardiac blood of drowned group have a lot of aquatic microbes, which have not been detected in postmortem submersion group. Furthermore, intra-alveolar granular staining of surfactant protein A (SP-A) was severely observed in the drowned group than the postmortem submersion and control groups. The findings suggested that the presence of aquatic microbiota in the closed organs and increased expression of SP-A could be markers for a diagnosis of drowning.
Angiosarcoma is a rare malignant tumor of the skin and soft tissue, and commonly metastasizes to the lungs, showing multiple nodules. The metastatic lung lesions rarely cavitate(1-5), though a angiosarcoma with cavitary metastasis can be complicated by hemopneumothorax(1-5). Metastatic lung lesions showing both cavities and pulmonary hemorrhage on high resolution CT have not, however, been reported. We describe a case of angiosarcoma of the scalp which rapidly developed cavitary lung metastasis, bilateral pneumothoraces, and diffuse pulmonary hemorrhage, and led to the patient s death.
Case ReportAn 85-year-old non-smoking man was admitted with dyspnea; its onset had been sudden, it persisted for a week and was accompanied by a cough, fresh hemoptysis and chest pain. Fifteen days before admission he had undergone excision biopsy of a soft tissue mass in the parietal area of the scalp. The histologic findings of the lesion were consistent with angiosarcoma involving the dermis and subcutaneous fat.The results of a pulmonary function test, performed on admission were normal. Cytologic examination of the sputum revealed no malignant cells, and sputum culture showed no bacterial growth.Initial chest radiograph showed increased interstitial markings and numerous thin-walled cavitary lesions in both lungs, small amount of pneumothorax was seen in the left pleural space. The chest radiograph obtained six days later showed an area of ground-glass opacity in the We describe a case of cavitary metastasis to the lungs from a small angiosarcoma of the scalp, in which the metastatic lesions were complicated by pneumothorax and pulmonary hemorrhage. On high-resolution CT, the lesions simulated the findings of Langerhans cell histiocytosis. Thin-walled cavitary metastatic lesions were similar to those of thin walled air cysts in Langerhans cell histiocytosis. Ground-glass opacity simulated the findings of smoke r s respiratory bronchiolitis in Langerhans cell histiocytosis but histologically represented hemorrhage during metastasis of the angiosarcom a .
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