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In a prospective, double-blinded study of 40 patients undergoing total hip replacement, the preoperative administration of tranexamic acid reduced bleeding by 35%, probably by decreasing induced fibrinolysis. Whether tranexamic acid therapy can replace predonation of autologous blood or intraoperative autotransfusion requires further study.

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A nucleoside diphosphate kinase has been highly purified from baker's yeast, and has been obtained in a crystalline form from an ethanol-containing medium. The results indicate that the amino acid sequence around the reactive 1-phosphohistidine of the yeast enzyme is different from that of human erythrocytic and bovine liver nucleoside diphosphate kinase.