Preemptive systemic administration of magnesium sulfate as the only drug can be used to prevent inflammatory pain in the orofacial region. Its analgesic effect is not associated with magnesium deficiency.
Background Magnesium is an antagonist of the N-methyl-D-aspartate receptor. This study aimed to investigate the anti-edematous effect of magnesium sulfate (MS) in different protocols of use and the possible mechanism of its action. Methods In a rat model of carrageenan-induced paw inflammation, the anti-edematous activity of MS was assessed with a plethysmometer. The effects of the nonselective inhibitor (L-NAME), selective inhibitor of neuronal (L-NPA) and inducible (SMT) nitric oxide synthase on the effects of MS were evaluated. Results MS administered systemically before or after inflammation reduced edema by 30% (5 mg/kg, P < .05) and 55% (30 mg/kg, P < .05). MS administered locally (.5 mg/paw, P < .05) significantly prevented the development of inflammatory edema by 60%. L-NAME, intraperitoneally administered before MS, potentiated (5 mg/kg, P < .05) or reduced (3 mg/kg, P < .05), while in the highest tested dose L-NPA (2 mg/kg, P < .01) and SMT (.015 mg/kg, P < .01) reduced the anti-edematous effect of MS. Conclusions Magnesium is a more effective anti-edematous drug in therapy than for preventing inflammatory edema. The effect of MS is achieved after systemic and local peripheral administration and when MS is administered as a single drug in a single dose. This effect is mediated at least in part via the production of nitric oxide.
Baclgrpund/Aim. Heart transplantation is the most effective way to treat
patients in the terminal stage of heart failure. Endomyocardial biopsy has
proven to be a safe and appropriate technique, with little sampling error
and remains to this day one of the most commonly used methods for diagnosing
of acute rejection. In 1990, ISHLT defined a standardized system for grading
the severity of acute transplant rejection regarding endomyocardial sampling
histopathological analysis. The aim of study is assessment of morphological,
immunohistochemical and immunofluorescent markers of cellular and
antibody-mediated rejection of heart transplant in patients monitored during
2020. Methods. From 31 patients transplanted at the Clinic for Cardiac
Surgery of the Clinical Center of Serbia, endomyocardial biopsy material was
obtained, then processed and analyzed at the Institute of Pathology of the
Medical Faculty, University of Belgrade. Results. The average Transplant
Rejection Score (TRS) value was 0.42. Spearman 's correlation test didn?t
show a statistically significant relationship between the TRS score value
and the difference between the ejection fraction values three and twelve
months after transplantation. Conclusion. The mean TRS score value obtained
in this study suggests dominant cell graft rejection.
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