Following notable cases of remarkable potency increases in methylated analogues of lead compounds, this review documents the state-of-the-art in C–H methylation technology.
An efficient three-step sequence to afford a valuable class of spirocyclic pyrrolidines is reported. A reductive cleavage/ Horner-Wadsworth-Emmons cascade facilitates the spirocyclisation of a range of isoxazolines bearing a distal...
The synthesis of α-tertiary ethers has traditionally presented a major challenge; however, contemporary redox chemistry has led to development of a plethora of powerful new approaches.
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