A rapid, on-site,
and accurate SARS-CoV-2 detection method is crucial for the prevention
and control of the COVID-19 epidemic. However, such an ideal screening
technology has not yet been developed for the diagnosis of SARS-CoV-2.
Here, we have developed a deep learning-based surface-enhanced Raman
spectroscopy technique for the sensitive, rapid, and on-site detection
of the SARS-CoV-2 antigen in the throat swabs or sputum from 30 confirmed
COVID-19 patients. A Raman database based on the spike protein of
SARS-CoV-2 was established from experiments and theoretical calculations.
The corresponding biochemical foundation for this method is also discussed.
The deep learning model could predict the SARS-CoV-2 antigen with
an identification accuracy of 87.7%. These results suggested that
this method has great potential for the diagnosis, monitoring, and
control of SARS-CoV-2 worldwide.
Laser interaction with a nanobrush target plasma is investigated at the SILEX-I laser facility [X. F. Wei et al., J. Phys. Conf. Ser. 112, 032010 (2008)] with a laser of intensity 7.9×1018 W/cm2. Highly collimated fast electron beams with yields of more than three times higher than that from the planar target can be produced. Two-dimensional particle-in-cell simulation confirms that a layered surface structure can increase the efficiency of laser energy absorption, and the resulting fast electrons are tightly collimated and guided by the plasma layers to a cross section of about the laser spot size.
A high-quality electron beam with a central energy of 0.56 GeV, an energy spread of 1.2% rms, and a divergence of 0.59 mrad rms was produced by means of a 4 cm ablative-capillary-discharge plasma channel driven by a 3.8 J 27 fs laser pulse. This is the first demonstration of electron acceleration with an ablative capillary discharge wherein the capillary is stably operated in vacuum with a simple system triggered by a laser pulse. This result of the generation of a high-quality beam provides the prospects to realize a practical accelerator based on laser-plasma acceleration.
X-ray ultraviolet absorption measurements of aluminum plasma at high temperature and high density are reported. A sample plasma was created by direct laser irradiation of a multilayered foil consisting of Au, CH, and Al. Observations were made using the method of self-backlighting spectroscopy. Simulations were performed with one-dimensional radiation-hydrodynamics code to compute the backlight profile as well as the time history of the density and temperature in the sample. By comparing the measured absorption spectra with detailed-term-accounting calculations at Te=120eV and ρ=0.1g∕cm3, it is found that the major spectral features predicted by calculations have been observed. Even better agreement between the experiment and the simulated absorption spectra was obtained by temporally averaging the radiation-hydrodynamics result over the backlight profile. This experiment shows that it is possible to measure high density and high temperature opacity by a laser-driven multilayer experiment.
We report a high-intensity laser facility named Xingguang-III that generates femtosecond, picosecond, and nanosecond beams with three wavelengths, i.e. 800 nm, 1053 nm, and 527 nm, respectively. To the best of our knowledge, the laser facility is the first one which produces three beams with different pulse widths and wavelengths. An optical synchronization technique, combining super continuum generation and femtosecond optical parametric amplification, was developed to ensure three beams are from the same source to achieve precise synchronization. The femtosecond beam is a double chirped-pulseamplification Ti:sapphire laser which applies cross-polarized wave generation to improve the temporal contrast. The picosecond/nanosecond beams utilize the optical parametric amplification + Nd:glass mixed amplification scheme. The output energy and pulse width of the three beams are 20.1 J/26.8 fs, 370.2 J/0.48 ps (shortest), and 575.4 J/1.0 ns, respectively. The smallest synchronization time (peak-to-valley) and the shot-to-shot timing jitter (peak-topeak) of less than 1.32 ps have been achieved for the femtosecond and picosecond beams.
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